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Table 5 Multivariable logistic regression analysis of risk factors for non-hematological adverse events

From: Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients

Variables

Grade 0–2

(N = 195)

Grade 3–4

(N = 39)

Univariate

Multivariate a)

OR (95% CI)

p

OR (95% CI)

p

Age (y)

   

0.83 (0.72–0.95)

0.007

1.06 (1.03–1.10)

0.000

Sex

F

72 (82.8%)

15 (17.2%)

1.07 (0.53–2.17)

0.856

  

M

123 (83.7%)

24 (24.55)

1.00

 

Operation type

Total

78 (83.9%)

15 (16.1%)

0.94 (0.46–1.90)

0.858

  

Distal

117 (83.05)

24 (17.0%)

1.00

 

Creatinine clearance (mL/min) b)

≥60

170 (86.3%)

27 (13.7%)

1.00

0.007

1.00

0.370

<60

25 (67.6%)

12 (32.4%)

3.02 (1.36–6.72)

1.52 (0.61–3.79)

Albumin (g/dL)

<3.5

25 (73.5%)

9 (26.5%)

2.04 (0.87–4.04)

0.102

  

≥3.5

170 (85.0%)

30 (15.0%)

1.00

BMI (kg/m2)

   

0.97 (0.85–1.10)

0.581

  

PG-SGA category

A

84 (87.5%)

12 (12.5%)

1.00

0.157

  

B

111 (80.4%)

27 (19.6%)

1.70 (0.82–3.56)

PG-SGA score

   

1.03 (0.91–1.17)

0.658

  

Weight loss (%)

   

0.96 (0.86–1.07)

0.442

  

NRI

   

0.95 (0.89–1.01)

0.083

  
  1. a)Covariates used in multivariate analyses included age and creatinine clearance; b)Creatinine clearance was calculated using the Cockroft–Gault formula; BMI Body Mass Index, PG-SGA Patient-Generated Subjective Global Assessment, NRI Nutritional Risk Index