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Table 5 Multivariable logistic regression analysis of risk factors for non-hematological adverse events

From: Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients

Variables Grade 0–2
(N = 195)
Grade 3–4
(N = 39)
Univariate Multivariate a)
OR (95% CI) p OR (95% CI) p
Age (y)     0.83 (0.72–0.95) 0.007 1.06 (1.03–1.10) 0.000
Sex F 72 (82.8%) 15 (17.2%) 1.07 (0.53–2.17) 0.856   
M 123 (83.7%) 24 (24.55) 1.00  
Operation type Total 78 (83.9%) 15 (16.1%) 0.94 (0.46–1.90) 0.858   
Distal 117 (83.05) 24 (17.0%) 1.00  
Creatinine clearance (mL/min) b) ≥60 170 (86.3%) 27 (13.7%) 1.00 0.007 1.00 0.370
<60 25 (67.6%) 12 (32.4%) 3.02 (1.36–6.72) 1.52 (0.61–3.79)
Albumin (g/dL) <3.5 25 (73.5%) 9 (26.5%) 2.04 (0.87–4.04) 0.102   
≥3.5 170 (85.0%) 30 (15.0%) 1.00
BMI (kg/m2)     0.97 (0.85–1.10) 0.581   
PG-SGA category A 84 (87.5%) 12 (12.5%) 1.00 0.157   
B 111 (80.4%) 27 (19.6%) 1.70 (0.82–3.56)
PG-SGA score     1.03 (0.91–1.17) 0.658   
Weight loss (%)     0.96 (0.86–1.07) 0.442   
NRI     0.95 (0.89–1.01) 0.083   
  1. a)Covariates used in multivariate analyses included age and creatinine clearance; b)Creatinine clearance was calculated using the Cockroft–Gault formula; BMI Body Mass Index, PG-SGA Patient-Generated Subjective Global Assessment, NRI Nutritional Risk Index