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Table 4 Multivariable logistic regression analysis of risk factors for hematological adverse events

From: Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients

Variables Grade 0–2
(N = 196)
Grade 3–4
(N = 38)
Univariate Multivariate a)
OR (95% CI) p OR (95% CI) p
Age (y)     0.99 (0.96–1.02) 0.472   
Sex Female 66 (75.9%) 21 (24.1%) 2.43 (1.20–4.92) 0.013 2.39 (1.15–4.96) 0.020
Male 130 (88.4%) 17 (11.6%) 1.00 1.00
Operation type Total 72 (77.4%) 21 (22.6%) 2.13 (1.05–4.29) 0.035 1.79 (0.86–3.74) 0.119
Distal 124 (87.9%) 17 (12.1%) 1.00 1.00
Creatinine clearance (mL/min) b) ≥60 165 (83.8%) 32 (16.2%) 1.00 0.997   
<60 31 (83.8%) 6 (16.2%) 0.99 (0.39–2.59)  
Albumin (g/dL) <3.5 24 (70.6%) 10 (29.4%) 2.56 (1.11–5.92) 0.028 2.45 (1.02–5.89) 0.045
≥3.5 172 (86.0%) 28 (14.0%) 1.00 1.00
BMI (kg/m2)     0.83 (0.72–0.95) 0.007 0.86 (0.74–0.99) 0.035
PG-SGA category A 78 (81.3%) 18 (18.8%) 1.00 0.078   
B 118 (85.5%) 20 (14.5%) 0.44 (0.17–1.09)
PG-SGA score     0.88 (0.76–1.01) 0.083   
Weight loss (%)     0.97 (0.88–1.07) 0.558   
NRI     0.96 (0.89–1.02) 0.163   
  1. a)Covariates used in multivariate analyses included sex, operation type, albumin, and BMI; b)Creatinine clearance was calculated using the Cockroft–Gault formula; BMI Body Mass Index, PG-SGA Patient-Generated Subjective Global Assessment, NRI Nutritional Risk Index