Table 3 Hematological and non-hematological adverse events (n = 234)
Events | Grade of chemotherapy toxicity (No (%)) | ||||||
|---|---|---|---|---|---|---|---|
Grade 0 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 3 + 4 (%) | ||
Hematological adverse events | Anemia | 29(12.4) | 153(65.4) | 45(19.2) | 7(3.0) | – | 3 |
Neutropenia | 94(40.2) | 41(17.5) | 67(28.6) | 31(13.2) | 1(0.4) | 13.6 | |
Thrombocytopenia | 150(64.1) | 73(31.2) | 10(4.3) | 1(0.4) | – | 0.4 | |
Febrile neutropenia | 233(99.6) | – | – | 1(0.4) | – | 0.4 | |
Leucopenia | 125(53.4) | 86(36.8) | 22(9.4) | 1(0.4) | – | 0.4 | |
Total | 14(6.0) | 95(40.6) | 87(37.2) | 37(15.8) | 1(0.4) | 16.2 | |
Non-hematological adverse events | Anorexia | 142(60.7) | 61(26.1) | 28(12.0) | 3(1.3) | – | 1.3 |
Nausea | 165(70.5) | 51(21.8) | 17(7.3) | 1(0.4) | – | 0.4 | |
Vomiting | 206(88.0) | 16(6.8) | 11(4.7) | 1(0.4) | – | 0.4 | |
Diarrhea | 119(50.9) | 58(24.8) | 43(18.4) | 14(6.0) | – | 6 | |
Constipation | 213(91.0) | 19(8.1) | 2(0.9) | – | – | 0 | |
Abdominal pain | 183(78.2) | 31(13.2) | 10(4.3) | 10(4.3) | – | 4.3 | |
Stomatitis | 191(81.6) | 26(11.1) | 15(6.4) | 2(0.9) | – | 0.9 | |
Hand-foot syndrome | 200(85.5) | 27(11.5) | 6(2.6) | 1(0.4) | – | 0.4 | |
Fatigue | 194(82.9) | 35(15.0) | 4(1.7) | 1(0.4) | – | 0.4 | |
Hyperpigmentation | 183(78.2) | 47(20.1) | 3(1.3) | 1(0.4) | – | 0.4 | |
Rash | 215(91.9) | 14(6.0) | 3 (1.3) | 2(0.9) | – | 0.8 | |
Elevated AST/ALT level | 149(63.7) | 77(32.9) | 5(2.1) | 3(1.3) | – | 1.3 | |
Elevated bilirubin level | 89(38.0) | 99(42.3) | 43(18.4) | 3(1.3) | – | 1.3 | |
Elevated creatinine level | 230(98.3) | 4(1.7) | – | – | – | 0 | |
Total | 10(4.3) | 99(23.1) | 86(36.8) | 39(16.7) | – | 16.7 | |