|
Events
|
Grade of chemotherapy toxicity (No (%))
|
|---|
|
Grade 0
|
Grade 1
|
Grade 2
|
Grade 3
|
Grade 4
|
Grade 3 + 4 (%)
|
|---|
|
Hematological adverse events
|
Anemia
|
29(12.4)
|
153(65.4)
|
45(19.2)
|
7(3.0)
|
–
|
3
|
|
Neutropenia
|
94(40.2)
|
41(17.5)
|
67(28.6)
|
31(13.2)
|
1(0.4)
|
13.6
|
|
Thrombocytopenia
|
150(64.1)
|
73(31.2)
|
10(4.3)
|
1(0.4)
|
–
|
0.4
|
|
Febrile neutropenia
|
233(99.6)
|
–
|
–
|
1(0.4)
|
–
|
0.4
|
|
Leucopenia
|
125(53.4)
|
86(36.8)
|
22(9.4)
|
1(0.4)
|
–
|
0.4
|
|
Total
|
14(6.0)
|
95(40.6)
|
87(37.2)
|
37(15.8)
|
1(0.4)
|
16.2
|
|
Non-hematological adverse events
|
Anorexia
|
142(60.7)
|
61(26.1)
|
28(12.0)
|
3(1.3)
|
–
|
1.3
|
|
Nausea
|
165(70.5)
|
51(21.8)
|
17(7.3)
|
1(0.4)
|
–
|
0.4
|
|
Vomiting
|
206(88.0)
|
16(6.8)
|
11(4.7)
|
1(0.4)
|
–
|
0.4
|
|
Diarrhea
|
119(50.9)
|
58(24.8)
|
43(18.4)
|
14(6.0)
|
–
|
6
|
|
Constipation
|
213(91.0)
|
19(8.1)
|
2(0.9)
|
–
|
–
|
0
|
|
Abdominal pain
|
183(78.2)
|
31(13.2)
|
10(4.3)
|
10(4.3)
|
–
|
4.3
|
|
Stomatitis
|
191(81.6)
|
26(11.1)
|
15(6.4)
|
2(0.9)
|
–
|
0.9
|
|
Hand-foot syndrome
|
200(85.5)
|
27(11.5)
|
6(2.6)
|
1(0.4)
|
–
|
0.4
|
|
Fatigue
|
194(82.9)
|
35(15.0)
|
4(1.7)
|
1(0.4)
|
–
|
0.4
|
|
Hyperpigmentation
|
183(78.2)
|
47(20.1)
|
3(1.3)
|
1(0.4)
|
–
|
0.4
|
|
Rash
|
215(91.9)
|
14(6.0)
|
3 (1.3)
|
2(0.9)
|
–
|
0.8
|
|
Elevated AST/ALT level
|
149(63.7)
|
77(32.9)
|
5(2.1)
|
3(1.3)
|
–
|
1.3
|
|
Elevated bilirubin level
|
89(38.0)
|
99(42.3)
|
43(18.4)
|
3(1.3)
|
–
|
1.3
|
|
Elevated creatinine level
|
230(98.3)
|
4(1.7)
|
–
|
–
|
–
|
0
|
|
Total
|
10(4.3)
|
99(23.1)
|
86(36.8)
|
39(16.7)
|
–
|
16.7
|
- AST/ALT aspartate transaminase/alanine transaminase
