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Table 2 Dose escalation scheme

From: A phase I dose-escalation study of PEP02 (irinotecan liposome injection) in combination with 5-fluorouracil and leucovorin in advanced solid tumors

Dose Level PEP02 (mg/m2) No. patients No. patients with DLT
I 60 3 0
II 80 3 + 3 0 + 0
III 100 3 + 2 0 + 2
IV 120 2 2
  1. Abbreviation: DLT dose-limiting toxicity