From: A phase I dose-escalation study of PEP02 (irinotecan liposome injection) in combination with 5-fluorouracil and leucovorin in advanced solid tumors
Dose Level
PEP02 (mg/m2)
No. patients
No. patients with DLT
I
60
3
0
II
80
3 + 3
0 + 0
III
100
3 + 2
0 + 2
IV
120
2