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Fig. 9 | BMC Cancer

Fig. 9

From: Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine

Fig. 9

Modulation of CAIX, ALDH1A1 and VEGF mRNA expression by Prima-1 ± 3-BrPA. Cells cultured as indicated in Fig. 4a was used for RT-qPCR to assay the effect of 3-BrPA and Prima-1 on CAIX, ALDH1A1 and VEGF normalized to ACTN gene expression under normoxia or 3 h of hypoxia: a and b Hypoxia –induced CAIX gene expression is inhibited by Prima-1 in MelJuso and C8161 cells. c and d ALDH1A1 gene expression is preferentially inhibited by Prima-1 irrespective of 3-BrPA in MelJuso cells compared to C8161 cells. e and f VEGF gene expression is preferentially inhibited by Prima-1 in MelJuso cells compared to C8161 cells. *denotes significance between treated cells relative to controls. **denotes significance between unequal treatments. ***denotes significance between hypoxia and normoxia

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