Fig. 5

Prima-1 and 3-BrPA preferentially decrease hypoxia-induced LDHA rather than GAPDH in A549 cells. RT-qPCR was used to assay the effect of 3-BrPA and Prima-1 on LDHA and GAPDH gene expression under normoxia or 3 h under hypoxia. Note that combined use of Prima-1 and 3-BrPA lowers hypoxic LDHA expression in about 40%, in contrast to only an approximate 25% decline in hypoxic GAPDH expression by the same combined treatment. *denotes significance between hypoxic and normoxic cells. **denotes significance between treated and control cells