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Table 2 Correlation analysis of the expression of wtERa, ERa36 and ER-beta with clinical features (cohort P)

From: Alternative splicing of estrogen receptor alpha in hepatocellular carcinoma

  Clinical features Pearson correlation analysis
   Correlation coefficient P valuea
wtERa Gender (Female vs. Male) 0.662 0.000
  Age (>58 vs. ≤58) 0.276 0.007
  International Normalized Ratio −0.442 0.000
  Size of the largest tumor (>5 cm vs. ≤5 cm) −0.306 0.003
  Intra-hepatic recurrence (Yes vs. No) −0.308 0.003
  Extra-hepatic metastasis (Yes vs. No) −0.310 0.002
  Adjuvant treatments after operation (Yes vs. No) −0.348 0.001
ERa36 Non-tumour liver (Cirrhosis vs. Fibrosis vs. Normal) 0.270 0.009
  Extra-hepatic metastasis (Yes vs. No) −0.274 0.007
  Pathological Grade (Poor vs. Moderate vs. Well) −0.274 0.007
  Liver cirrhosis (Yes vs. No) 0.267 0.009
ERb Gender (Female vs. Male) 0.234 0.023
  Age (>58 vs. ≤58) 0.308 0.002
  International Normalized Ratio −0.273 0.009
  HBsAg (+ vs. -) −0.377 0.000
  1. a Correlation is significant at the 0.01 level (2-tailed)