|First author||Study design||N||Population||Mean age||Intervention||Primary end-point||Results|
|Bourdel-Marchasson ||Multicenter RCT*||336||Patients with solid tumor treated by chemotherapy at risk of malnutrition (17 ≤ MNA ≤ 23.5).||78.0y||3–6 months diet counselling intervention||1-year mortality||- Early dietary counselling was efficient in increasing intake but had no beneficial effect on mortality.|
|Hempenius ||Multicenter RCT||260||Frail elderly patients undergoing elective surgery for a solid tumor||≈77.5y||Geriatric liaison intervention||Postoperative delirium||- Intervention for frail elderly cancer patients receiving surgery to prevent post-operative delirium was not effective.|
|Demark-Wahnefried ||Multicenter international RCT (RENEW study)||641||Overweight long-term survivors (≥5 years) of colorectal, breast and prostate cancer||≈73y||12-month diet and exercise intervention via telephone counseling and print materials||
Change in functional status (baseline/12-month and 24-month)|
Diet quality, BMI and physical activity
|- Significant change in functional status between intervention group and control group (p < 0.01): amelioration of functional decline in intervention group. Significant change in diet quality, physical activity and BMI (p < 0.01).|
|Morey ||Change in functional status (baseline/12 m) using the Medical Outcomes Study SF36 questionnaire, health-related QoL||- Significant change in physical function (p = 0.03) and QoL (p = 0.007) between groups.|
|Lapid ||Subset geriatric analysis from stratified, two-group RCT||33||New advanced cancer diagnosis (5-year OS: 0–50 %) planned to receive radiotherapy||≈72y||4-week multidisciplinary QoL intervention||QoL measured with Spitzer uniscale and linear analogue self-assessment (LASA) at baseline and weeks 4, 8, and 27||- Significant improvement in QoL (p < 0.05) at baseline, maintained at 4 and 8 weeks.|
|Rao ||Subset analysis from RCT ||99||Frail elderly cancer patients hospitalized on a medical or surgical ward (≥2 days)||≈74y||Geriatric assessment and patient management by a geriatric attending physician and a social worker||12-month survival and health-related QoL (after randomization), ADL, physical performance, health service utilization, and costs||
- No significant effect on survival or QoL parameters.|
Positive effects of geriatric inpatient care on mental health and bodily pain (p < 0.05).
Days of hospitalization and cost similar.
|Goodwin ||Multicenter RCT||335||Older women (≥65y) newly (<2 months) diagnosed with breast cancer||≈72y||12-month nurse case management||
Type and use of cancer-specific therapies received in the first 6 months after diagnosis.|
Patient satisfaction and arm function
- More appropriate management for women receiving nurse case management (Breast-conserving surgery, adjuvant radiation, radiation therapy, axillary dissection and breast reconstruction surgery).|
Better arm function and higher satisfaction in intervention group.
|McCorkle ||Single centerRCT||375||Old patients (≥60y) newly diagnosed with solid cancer||60–92||4-week home-based case management by nurse||Length of survival||
- Longer survival in intervention group than in usual care group (p = 0.001).|
Survival advantage for intervention group in late stage patients.
|Galvao ||Two-arm single center RCT||57||Prostate cancer patient without bone metastases treated by AST (≥2 months)||≈70y||12-week progressive resistance and aerobic training (2/week) by an exercise physiologist||Muscle mass, strength, physical function, QoL||- Significant change in total body lean mass, muscle strength and endurance (p < 0.05). Change in QoL for general health (p = 0.022), vitality (p = 0.019) and physical health composite score (p = 0.02).|