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Table 1 Mutational status of colorectal cancer critical genes [44, 51–55]

From: Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors

CRC cell line

Oncogenes

Tumor suppressor genes

KRAS

BRAF

TP53

MLH1

HCT116

G13D / wt

wt / wt

wt / wt

S252* / S252* a

DLD-1

G13D / wt

wt / wt

S241F / wt (sil)

wt / wt b

DKs-8

- / wt

wt / wt

S241F / wt (sil)

wt / wt b

HT-29

wt / wt

V600E / wt

R273H / R273H

wt (m) / wt c

  1. Wt wild-type; sil silenced; m methylated; *nonsense mutation
  2. aHCT116 cells are MMR-deficient due to mutations in MLH1 and mutS homolog 3 (MSH3) genes
  3. bDLD-1 and DKs-8 cells are MMR-deficient due to mutation in mutS homolog 3 (MSH6) gene
  4. cHT-29 cells are MMR-proficient
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BMC Cancer

ISSN: 1471-2407

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