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Table 2 Cox regression analysis of ANLN NF in relation to OS, BCSS and RFS

From: ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer

 

Univariable analysis

Multivariable analysis

HR (95% CI)

p-value

HR (95% CI)

p-value

Cohort I

 OS

2.05 (1.10–3.82)

0.024

1.93 (1.03–3.62)

0.039 a

 BCSS

2.34 (1.00–5.47)

0.051

  

 RFS

1.88 (0.90–3.97)

0.095

  

Cohort II

 OS

1.91 (1.39–2.63)

<0.001

1.61 (1.09–2.39)

0.018 b

 BCSS

1.93 (1.38–2.69)

<0.001

1.58 (1.05–2.38)

0.027 b

 RFS

1.75 (1.27–2.40)

0.001

1.67 (1.13–2.48)

0.010 b

  1. Low ANLN NF(ref) vs high ANLN NF
  2. HR hazard ratio, CI confidence interval, ref referent group, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2
  3. Significant correlations (p < 0.05) are indicated by bold numbers
  4. aMultivariable analysis included adjustment for age
  5. bMultivariable analysis included adjustment for Ki-67, tumor size, ER, PR, HER2, nodal status and age
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BMC Cancer

ISSN: 1471-2407

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