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Table 2 Cox regression analysis of ANLN NF in relation to OS, BCSS and RFS

From: ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer

  Univariable analysis Multivariable analysis
HR (95% CI) p-value HR (95% CI) p-value
Cohort I
 OS 2.05 (1.10–3.82) 0.024 1.93 (1.03–3.62) 0.039 a
 BCSS 2.34 (1.00–5.47) 0.051   
 RFS 1.88 (0.90–3.97) 0.095   
Cohort II
 OS 1.91 (1.39–2.63) <0.001 1.61 (1.09–2.39) 0.018 b
 BCSS 1.93 (1.38–2.69) <0.001 1.58 (1.05–2.38) 0.027 b
 RFS 1.75 (1.27–2.40) 0.001 1.67 (1.13–2.48) 0.010 b
  1. Low ANLN NF(ref) vs high ANLN NF
  2. HR hazard ratio, CI confidence interval, ref referent group, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2
  3. Significant correlations (p < 0.05) are indicated by bold numbers
  4. aMultivariable analysis included adjustment for age
  5. bMultivariable analysis included adjustment for Ki-67, tumor size, ER, PR, HER2, nodal status and age