Table 1 Clinical factors and systemic inflammatory status of patients receiving EGFR-TKI readministration

Length of EGFR-TKI holiday

0.235

  < 3

16 (20.0)

3.8

 3–6

25 (31.3)

6.7

  > 6

39 (48.8)

8.4

PFS of first-line EGFR-TKI

0.020

<0.001

  < 6

17 (35.0)

3.5

4.970

2.170–11.382

 6–12

35 (43.8)

7.2

1.818

0.899–3.678

  > 12

28 (21.3)

9.9

1

Changes in the EGFR-TKI regimen

0.474

 Yes

75 (93.8)

7.2

 No

5 (6.2)

8.4

Type of EGFR-TKI readministrated

0.934

 1^st generation

71 (88.8)

7.0

 2^nd generation

9 (11.2)

7.4

Baseline NLR

<0.001

0.037

  > 5.2

27 (34.6)

3.2

2.352

1.052–5.256

  ≤ 5.2

51 (65.4)

8.4

1

Trend of NLR

0.129

  > 110 %

44 (57.1)

4.3

  ≤ 110 %

33 (42.9)

8.4

Baseline LMR

0.006

0.632

  > 2.5

37 (46.8)

8.3

1

  ≤ 2.5

41 (53.2)

4.2

1.197

0.574–2.497

Trend of LMR

0.037

0.004

  > 50 %

45 (58.4)

7.9

1

  ≤ 50 %

32 (41.6)

4.1

2.651

1.374–5.118