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Fig. 5 | BMC Cancer

Fig. 5

From: Binding of galectin-1 to breast cancer cells MCF7 induces apoptosis and inhibition of proliferation in vitro in a 2D- and 3D- cell culture model

Fig. 5

Measurement of the metabolic activity of human breast cancer cells in spheroid culture in the ATP assay. Significant decrease of metabolic activity could be reached by incubation of MCF-7 cells with 30 μg/ml gal-1 compared to untreated cells (p = 0.027). In combination with 1xPPC FEC (p = 0.016) or 1xPPC TAC (p = 0.031) 30 μg/ml gal-1 further significantly reduced the metabolic activity compared to FEC or TAC alone (a). In T-47D cells treatment with 30 μg/ml gal-1 could not significantly reduce the metabolic activity compared to untreated cells. Neither did the addition of 30 μg/ml gal-1 to 1xPPC FEC or 1xPPC TAC significantly alter the rate of metabolic activity compared to FEC or TAC alone (b)

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BMC Cancer

ISSN: 1471-2407

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