Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer

Table 4 Results of correlation analysis using Pearson’s test for tissue and serum concentrations of activin-A, activin-B, activin-AB and follistatin with the numbers (N) and surface areas (SA) of the different types of colonic lesions (*P < 0.05)

			Large ACF		Flat ACF		MDF		Adenoma		Carcinoma		Tumours
			N	SA	N	SA	N	SA	N	SA	N	SA	Gross	Micro
Activin-A (pg/mL)	Tissue	R Value	0.123	0.271^*	0.364^*	0.288^*	0.416^*	0.383^*	0.027	0.091	0.589^*	0.471^*	0.389^*	0.352^*
	Tissue	P Value	0.7	0.008	0.03	0.004	0.0001	0.003	0.9	0.8	0.003	0.02	0.02	0.03
	Serum	R Value	0.082	0.071	0.101	0.089	0.091	0.062	0.051	0.009	0.397^*	0.312^*	0.256^*	0.299^*
	Serum	P Value	0.8	0.8	0.7	0.8	0.7	0.9	0.9	1	0.03	0.04	0.03	0.03
Activin-B (pg/mL)	Tissue	R Value	−0.091	−0.103	−0.053	−0.071	−0.304^*	−0.218^*	−0.086	−0.091	−0.205^*	−0.171	−0.005	−0.091
	Tissue	P Value	0.7	0.7	0.5	0.6	0.002	0.03	0.3	0.4	0.03	0.1	0.9	0.4
	Serum	R Value	0.008	0.062	−0.003	−0.098	−0.004	−0.062	0.054	0.003	−0.037	0.011	0.063	0.019
	Serum	P Value	0.9	0.8	0.8	0.8	0.9	0.7	0.7	0.9	0.5	0.7	0.6	0.5
Activin-AB (pg/mL)	Tissue	R Value	0.019	−0.032	0.062	0.051	−0.342^*	−0.288^*	0.079	0.009	−0.377^*	−0.311^*	−0.289^*	−0.300^*
	Tissue	P Value	0.8	0.8	0.4	0.4	0.002	0.01	0.3	0.9	0.009	0.02	0.007	0.006
	Serum	R Value	0.002	0.007	0.011	−0.092	−0.003	0.044	−0.007	−0.009	−0.104	−0.012	−0.100	−0.112
	Serum	P Value	0.9	0.8	0.8	0.8	1	0.9	1	1	0.4	0.8	0.4	0.7
Follistatin (ng/mL)	Tissue	R Value	0.144	0.171	0.164^*	0.118	0.389^*	0.299^*	0.007	0.009	0.498^*	0.412^*	0.311^*	0.243^*
	Tissue	P Value	0.08	0. 4	0.03	0.4	0.001	0.005	0.8	0.8	0.002	0.004	0.02	0.03
	Serum	R Value	0.002	0.051	0.091	0.009	0.001	0.055	0.062	0.019	0.333^*	0.302^*	0.187^*	0.111
	Serum	P Value	1	0.8	0.7	0.9	1	0.9	0.9	0.9	0.004	0.006	0.02	0.1

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