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Table 4 Results of correlation analysis using Pearson’s test for tissue and serum concentrations of activin-A, activin-B, activin-AB and follistatin with the numbers (N) and surface areas (SA) of the different types of colonic lesions (*P < 0.05)

From: Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer

  Large ACF Flat ACF MDF Adenoma Carcinoma Tumours
N SA N SA N SA N SA N SA Gross Micro
Activin-A (pg/mL) Tissue R Value 0.123 0.271* 0.364* 0.288* 0.416* 0.383* 0.027 0.091 0.589* 0.471* 0.389* 0.352*
P Value 0.7 0.008 0.03 0.004 0.0001 0.003 0.9 0.8 0.003 0.02 0.02 0.03
Serum R Value 0.082 0.071 0.101 0.089 0.091 0.062 0.051 0.009 0.397* 0.312* 0.256* 0.299*
P Value 0.8 0.8 0.7 0.8 0.7 0.9 0.9 1 0.03 0.04 0.03 0.03
Activin-B (pg/mL) Tissue R Value −0.091 −0.103 −0.053 −0.071 −0.304* −0.218* −0.086 −0.091 −0.205* −0.171 −0.005 −0.091
P Value 0.7 0.7 0.5 0.6 0.002 0.03 0.3 0.4 0.03 0.1 0.9 0.4
Serum R Value 0.008 0.062 −0.003 −0.098 −0.004 −0.062 0.054 0.003 −0.037 0.011 0.063 0.019
P Value 0.9 0.8 0.8 0.8 0.9 0.7 0.7 0.9 0.5 0.7 0.6 0.5
Activin-AB (pg/mL) Tissue R Value 0.019 −0.032 0.062 0.051 −0.342* −0.288* 0.079 0.009 −0.377* −0.311* −0.289* −0.300*
P Value 0.8 0.8 0.4 0.4 0.002 0.01 0.3 0.9 0.009 0.02 0.007 0.006
Serum R Value 0.002 0.007 0.011 −0.092 −0.003 0.044 −0.007 −0.009 −0.104 −0.012 −0.100 −0.112
P Value 0.9 0.8 0.8 0.8 1 0.9 1 1 0.4 0.8 0.4 0.7
Follistatin (ng/mL) Tissue R Value 0.144 0.171 0.164* 0.118 0.389* 0.299* 0.007 0.009 0.498* 0.412* 0.311* 0.243*
P Value 0.08 0. 4 0.03 0.4 0.001 0.005 0.8 0.8 0.002 0.004 0.02 0.03
Serum R Value 0.002 0.051 0.091 0.009 0.001 0.055 0.062 0.019 0.333* 0.302* 0.187* 0.111
P Value 1 0.8 0.7 0.9 1 0.9 0.9 0.9 0.004 0.006 0.02 0.1