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Table 1 Mean ± SD of body weight, colon surface area (length X width in cm), count of colonic tumours by gross and dissecting microscope, number of tumour/colon surface area ratio (NT/CS), numbers and median surface areas of large (≥4 crypts/focus) and flat ACFs, adenoma and adenocarcinoma in the different study groups

From: Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer

  Control group
(n = 20)
S-AOM group
(n = 30)
L-AOM group
(n = 30)
Body weight (g) 231.57 ± 20.01 221.97 ± 23.01 179.6 ± 15.64b,d
Colon surface area (cm2) 19.1 ± 2.2 18.89 ± 3.43 17.81 ± 1.84a
Tumour count Gross ND 7.2 ± 2.9 12.5 ± 3.21d
Dissecting Microscope ND 15.4 ± 5.1 24.8 ± 5.9d
Total N/A 23.1 ± 3.7 35.3 ± 4.1d
NT/CS Ratio N/A 1.33 ± 0.4 1.95 ± 0.2c
Dissecting microscope (×20 magnification) large ACF Numbers 1.1 ± 0.2 69.4 ± 10.2b 143.2 ± 26.1b,d
Median surface area (mm2) 4.1 (range 2.4–7.1) 29.7 (range 7.3–42.4)b 85.3 (range 7.9–133.3)b,d
Flat ACF Numbers ND 18.4 ± 7.3 31.2 ± 9.6c
Median surface area (mm2) N/A 21.2 (range 8–51.7)b 69.4 (range 9.3–91.8) d
Light microscope MDF (×200 magnification) Numbers ND 17.4 ± 3.1 29.1 ± 3.6d
Median surface area (μm2) N/A 161.5 (range 12.2–352.9) 596.4 (range 142.8–966.3)d
Adenoma (×100 magnification) Numbers ND 9.8 ± 3.1 11.6 ± 2.8
Median surface area (μm2) N/A 353.6 (range 101.7–507.8) 728.3 (range 274.8–1396.7)d
Adenocarcinoma (×100 magnification) Numbers ND 16.7 ± 4.1 82.6 ± 15.7d
Median Surface area (μm2) N/A 107.9 (range 48–251.7) 711.8 (range 222.8–1808.4)d
  1. N/A not applicable, ND not detected, aP < 0.05 compared with control; bP < 0.01 compared with control, cP < 0.05 compared with S-AOM group and dP < 0.01 compared with S-AOM group