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Table 1 Mean ± SD of body weight, colon surface area (length X width in cm), count of colonic tumours by gross and dissecting microscope, number of tumour/colon surface area ratio (NT/CS), numbers and median surface areas of large (≥4 crypts/focus) and flat ACFs, adenoma and adenocarcinoma in the different study groups

From: Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer

 

Control group

(n = 20)

S-AOM group

(n = 30)

L-AOM group

(n = 30)

Body weight (g)

231.57 ± 20.01

221.97 ± 23.01

179.6 ± 15.64b,d

Colon surface area (cm2)

19.1 ± 2.2

18.89 ± 3.43

17.81 ± 1.84a

Tumour count

Gross

ND

7.2 ± 2.9

12.5 ± 3.21d

Dissecting Microscope

ND

15.4 ± 5.1

24.8 ± 5.9d

Total

N/A

23.1 ± 3.7

35.3 ± 4.1d

NT/CS Ratio

N/A

1.33 ± 0.4

1.95 ± 0.2c

Dissecting microscope (×20 magnification)

large ACF

Numbers

1.1 ± 0.2

69.4 ± 10.2b

143.2 ± 26.1b,d

Median surface area (mm2)

4.1 (range 2.4–7.1)

29.7 (range 7.3–42.4)b

85.3 (range 7.9–133.3)b,d

Flat ACF

Numbers

ND

18.4 ± 7.3

31.2 ± 9.6c

Median surface area (mm2)

N/A

21.2 (range 8–51.7)b

69.4 (range 9.3–91.8) d

Light microscope

MDF (×200 magnification)

Numbers

ND

17.4 ± 3.1

29.1 ± 3.6d

Median surface area (μm2)

N/A

161.5 (range 12.2–352.9)

596.4 (range 142.8–966.3)d

Adenoma (×100 magnification)

Numbers

ND

9.8 ± 3.1

11.6 ± 2.8

Median surface area (μm2)

N/A

353.6 (range 101.7–507.8)

728.3 (range 274.8–1396.7)d

Adenocarcinoma (×100 magnification)

Numbers

ND

16.7 ± 4.1

82.6 ± 15.7d

Median Surface area (μm2)

N/A

107.9 (range 48–251.7)

711.8 (range 222.8–1808.4)d

  1. N/A not applicable, ND not detected, aP < 0.05 compared with control; bP < 0.01 compared with control, cP < 0.05 compared with S-AOM group and dP < 0.01 compared with S-AOM group