Fig. 3

Immunohistochemical expression of activin IIB receptor (left column), phosphorylated smad2 (middle column) and smad3 (right column) in normal colonic mucosa from control (a, b & c), pre-neoplastic lesions from S-AOM group (d to i), adenocarcinoma (j, k & l) and serosal metastatic foci (m, n & o) from the L-AOM group. (Red star = large dysplastic ACF and yellow star = MDF; ×200 magnification, scale bar = 8 μm)