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Fig. 2 | BMC Cancer

Fig. 2

From: Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway

Fig. 2

The inhibitory effects let-7 on HCC cells. a. After let-7 miRNAs were successfully overexpressing in HCC cells, the effects of let-7 on cell proliferation were detected by MTT assay. Let-7a was demonstrated to exert the strongest repression on cell proliferation, defined by student t test and Two-way ANOVA, * p < 0.01. Let-7a induced more cell apoptosis in MHCC97-H and HCCLM3 cells (b); let-7a also increased the portion of cells staying in G0-G1 stage and decreased the cells in S phase (c), compared to Scramble group. * p < 0.01. The representative images of the FACS derived apoptosis ratios (d) and FACS derived cell cycle analysis (e)

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