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Fig. 1 | BMC Cancer

Fig. 1

From: Vorinostat enhances the cisplatin-mediated anticancer effects in small cell lung cancer cells

Fig. 1

Effects of triple combination treatments of vorinostat with cisplatin and etoposide on the viability and apoptosis of SCLC cells. H209 and H146 cells were treated with or without vorinostat in combination with cisplatin (a vorinostat at 0.8 μM, and cisplatin and etoposide both at 1 μM; b vorinostat at 0.4 μM, cisplatin at 0.2 μM, and etoposide at 0.6 μM) for 24 h. Cell viability was determined using the MTS assay, and data were represented as mean ± SD in triplicate. A significant reduction in cell viability was documented (*, P < 0.05; **, P < 0.01; ***, P < 0.001) compared with vorinostat or cisplatin/etoposide alone. c, d PARP cleavage was used for determining apoptosis. The cells were treated with the same triple combination treatment described previously for 24 h, and cell lysates were collected and subjected to Western blot analysis with PARP and α-tubulin

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