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Table 1 Correlation of HMGB1 expression with known clinicopathologic characteristics in peritumoral liver tissue and in tumor tissue in 149 HCC cases

From: High-mobility group protein box1 expression correlates with peritumoral macrophage infiltration and unfavorable prognosis in patients with hepatocellular carcinoma and cirrhosis

  Peri-HMGB1 expression Intra-HMGB1 expression
Features Low High p value Low High p value
Age
  ≤ 55 55 36   32 59  
  > 55 35 23 0.563 23 35 0.277
Gender
 Male 53 29   36 46  
 Female 37 30 0.159 19 48 0.055
a-Fetoprotein
  ≤ 400 ng/ml 67 43   37 73  
  > 400 ng/ml 23 16 0.489 18 21 0.116
Tumor size (mean ± SD, cm)
  ≤ 5 cm 75 47   47 75  
  > 5 cm 15 12 0.360 8 19 0.262
Encapsulation/none
 Complete 38 36   22 52  
 Incomplete 52 23 0.019 33 42 0.051
Tumor differentiation
 I-II 70 45   43 72  
 III-IV 20 14 0.491 22 22 0.496
BCLC stage
 I 60 48   35 73  
 II-III 30 11 0.036 20 21 0.049
Recurrence
 Yes 27 34   22 39  
 No 63 25 0.001 33 55 0.022