Fig. 7

Salinomycin down-regulates the mRNA expression of Fibronectin and Lgr5 in human CD133⁺/CD133^- colorectal cancer cells. The mRNA expression levels of Fibronectin (a + b) and Lr5 (c + d) in CD133⁺/CD133^- SW620 and CD133⁺/CD133^- HT29 cells were measured by quantitative PCR after treatment with1 μM 5-FU or increasing concentrations of Salinomycin (1, 2, 5 and 10 μM). * p < 0.05, ** p < 0.001 compared to control