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Table 1 Summary of the suggestive risk factor for poor prognosis in MEC

From: Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

High risk
 Histological findings: Spindle cell type [3]
 IHC for p53, p63 is positive, Ki67 labeling index is high [1, 3, 5]
 Clinical stage, size, extensive invasion into the surrounding tissue, perineural invasion [2, 12, 19]
Low risk
 Site of origin: a minor salivary gland [17]
 Histological findings: Clear cell component [20]
Unknown or Equivalent or controversial
 MC derived from benign tumor, PA, or myoepithelioma [2, 21]