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Fig. 5 | BMC Cancer

Fig. 5

From: Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer

Fig. 5

Growth inhibition of A2780/DDP derived tumors in the tumor xenograft models. a Typical photographs of mice bearing A2780/DDP tumors after the different treatment. Representative photographs from each group. b The tumor growth curve for the different treatment groups (n = 5 in each group). The tumors’ volume in the experiment groups were significantly smaller compared to that in the PBS control group (p < 0.05), and the mice in the treatment group of LHRHa-BJOLs manifested the slowest tumor growth rate. c Western blot analysis of the expression bcl-2, bax and caspase 3 protein in tumor tissue after different treatments, LHRHa-BJOLs group showed more prominent bands of bax and caspase 3 and less band of bcl-2 than other treatment groups (n = 3 in each group). d The expression levels of bcl-2, bax and caspase 3 protein in different treatments groups. LHRHa-BJOLs group has the highest expression of bax and caspase-3 and the lowest expression of bcl-2, and the differences were statistically significant (n = 3 in each group). Compared with control group, *p < 0.05; Compared with LHRHa-BJOLs group, #p < 0.05

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