TY - JOUR AU - Ye, Hongxia AU - Liu, Xiaojuan AU - Sun, Jiangchuan AU - Zhu, Shenyin AU - Zhu, Yi AU - Chang, Shufang PY - 2016 DA - 2016/10/29 TI - Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer JO - BMC Cancer SP - 831 VL - 16 IS - 1 AB - Although brucea javanica oil liposomes (BJOLs) have been used clinically to treat ovarian cancer, its clinical efficacy is often limited by systemic side effects due to non-specific distribution. Luteinizing hormone releasing hormone receptor (LHRHR) is overexpressed in most ovarian cancers but negligibly expressed in most of the other visceral organs. In this study, we aimed to develop a novel LHRHa targeted and BJO-loaded liposomes (LHRHa-BJOLs), and investigate its characteristics, targeting ability and anti-ovarian cancer efficiency both in vitro and in vivo. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-016-2870-4 DO - 10.1186/s12885-016-2870-4 ID - Ye2016 ER -