Fig. 2
From: LPA receptor 1 mediates LPA-induced ovarian cancer metastasis: an in vitro and in vivo study
Effects of silencing LPA1-3 on ovarian cancer cells’ response for LPA-induced invasion. a SK-OV3 and HEY cells were transduced with control or LPAR1-3 shRNAs and then analyzed for cell invasion with or without 20 μM LPA contained in the underwells. Results are presented as fold increase of cell invasion (OD600 LPA-induced cell invasion /OD600 base cell invasion). Data are means SE. n = 3. Differences between groups were assessed using Student t test. b We lentivirally overexpressed LPAR1 in I IGROV1, TOV21G and OVCAR3 lines. Enforced LPAR1 expression was unable to render non-metastatic IGROV1, TOV21G and OVCAR3 cells responding to LPA for cell invasion