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Table 3 Cox proportional hazard models for six tumor types using standardized mean values for the gene signature as variables

From: The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer

  Univariate Multivariate
  HR p-val HR p-val
A) ECM
 BRCA 0.961 0.784 1.002 0.991
 COAD 0.823 0.387 0.735 0.397
 HNSC 0.934 0.697 0.868 0.525
 KIRC 1.321 0.014 1.434 0.003
 LUAD 1.505 0.005 1.533 0.004
 LUSC 1.268 0.047 1.144 0.331
B) Endothelial
 BRCA 0.927 0.564 0.926 0.612
 COAD 0.903 0.670 1.170 0.689
 HNSC 1.032 0.851 1.122 0.591
 KIRC 0.816 0.088 0.729 0.015
 LUAD 1.018 0.898 0.915 0.561
 LUSC 1.286 0.025 1.202 0.160
C) Breast cancer
 ECM 1.174 0.290   
 Endothelial 0.905 0.470   
 Estrogen receptor 0.429 <0.001   
 Tumor size 2.363 0.014   
 Node status 2.120 0.004   
  1. In A and B the signatures were either tested in univariate models or together in multivariate models stratified for age and stage. In C the model also included estrogen receptor status (+/−), tumor size (<2 vs >2 cm), and node status (+/−). All data are from TCGA cancer sets