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Table 3 Cox proportional hazard models for six tumor types using standardized mean values for the gene signature as variables

From: The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer

 

Univariate

Multivariate

 

HR

p-val

HR

p-val

A) ECM

 BRCA

0.961

0.784

1.002

0.991

 COAD

0.823

0.387

0.735

0.397

 HNSC

0.934

0.697

0.868

0.525

 KIRC

1.321

0.014

1.434

0.003

 LUAD

1.505

0.005

1.533

0.004

 LUSC

1.268

0.047

1.144

0.331

B) Endothelial

 BRCA

0.927

0.564

0.926

0.612

 COAD

0.903

0.670

1.170

0.689

 HNSC

1.032

0.851

1.122

0.591

 KIRC

0.816

0.088

0.729

0.015

 LUAD

1.018

0.898

0.915

0.561

 LUSC

1.286

0.025

1.202

0.160

C) Breast cancer

 ECM

1.174

0.290

  

 Endothelial

0.905

0.470

  

 Estrogen receptor

0.429

<0.001

  

 Tumor size

2.363

0.014

  

 Node status

2.120

0.004

  
  1. In A and B the signatures were either tested in univariate models or together in multivariate models stratified for age and stage. In C the model also included estrogen receptor status (+/−), tumor size (<2 vs >2 cm), and node status (+/−). All data are from TCGA cancer sets
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BMC Cancer

ISSN: 1471-2407

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