The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer

BMC Cancer

Table 2 Endothelial gene signatures in TCGA cancer sets

BRCA	COAD	COAD cont	HNSC	KIRC	KIRC cont	LUAD	LUSC
ARHGEF15	ARHGEF15	MMRN2	CD34	ARHGEF15	LDB2	ARHGEF15	CD93
CD34	BCL6B	MYCT1	CDH5	BCL6B	MMRN2	CD34	CDH5
CDH5	CALCRL	PCDH12	CXorf36	CD34	MYCT1	CDH5	CXorf36
CXorf36	CD34	RHOJ	ELTD1	CDH5	NOTCH4	CXorf36	TIE1
ELTD1	CD93	S1PR1	ESAM	CLEC14A	PCDH12	TIE1
ERG	CDH5	SH2D3C	RHOJ	CXorf36	PLVAP
ESAM	CLEC14A	SHE	TIE1	DLL4	ROBO4
LDB2	CXorf36	TEK		ECSCR	S1PR1
MMRN2	ELTD1	TIE1		ELTD1	TIE1
MYCT1	ERG			ERG
TIE1	GPR116			ESAM
	LDB2			GPR4

The signatures were defined by an iterative process. Starting with the expanded endothelial gene set (Additional file 10: Table S5) the gene with the lowest mean value of the correlation coefficients of the log2 expression with the genes in the set was removed from the set. The process was reiterated until all genes had a mean correlation coefficient above 0.85

ISSN: 1471-2407