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Fig. 4 | BMC Cancer

Fig. 4

From: The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer

Fig. 4

Hazard ratios of gene sets with opposing prognostic association in different cancer data sets. Lines represent confidence intervals (95 %) from multivariate Cox proportional hazard analyses using mean log2 expression of the genes in the prognostic ECM gene signatures (listed on top of the figure) stratifying for age and stage. Red lines and font represent the signature associated with poor prognosis and blue lines and font the signature associated with good prognosis when both signatures are evaluated in a multivariate Cox model. For the TCGA breast cancer (BRCA, which was used for training) and the breast cancer microarray sets (GEOD21653 and EMTAB365) the model was adjusted for node and ER status. The TCGA data sets are colon adenocarcinoma (COAD), head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC)

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