Skip to main content

Table 5 Association of the BRCA1-like profile with clinical parameters

From: Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study

Variable Valid cases MLPA data p-value
  (n) BRCA1-like Non-BRCA1-like  
Total 144 63 81  
Age 143    0.265
 <50 54 27 27  
 ≥50 89 36 53  
Tumor size 143    0.979
 pT 1 54 24 30  
 pT 2 69 31 38  
 pT 3 8 3 5  
 pT 4 12 5 7  
Nodal status 141    0.145
 Negative 71 35 36  
 Positive 70 26 44  
Histological grade 139    0.0004*
 1 6 0 6  
 2 28 5 23  
 3 105 57 48  
Histology 144    0.062
 Invasive-ductal 113 53 60  
 Invasive-medullary 11 6 5  
 Other 20 4 16  
Adjuvant chemotherapy 142    0.044*
 None 34 10 24  
 Yes 108 53 55  
Radiation therapy 142    0.017*
 None 23 5 18  
 Yes 119 58 61  
  1. BRCA1-like classification with cut-off value ≥ 0.5, non-BRCA1-like classification with cut-off value < 0.5
  2. *statistically significant with chi square test