Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study

Table 5 Association of the BRCA1-like profile with clinical parameters

Variable	Valid cases	MLPA data		p-value
	(n)	BRCA1-like	Non-BRCA1-like
Total	144	63	81
Age	143			0.265
<50	54	27	27
≥50	89	36	53
Tumor size	143			0.979
pT 1	54	24	30
pT 2	69	31	38
pT 3	8	3	5
pT 4	12	5	7
Nodal status	141			0.145
Negative	71	35	36
Positive	70	26	44
Histological grade	139			0.0004*
1	6	0	6
2	28	5	23
3	105	57	48
Histology	144			0.062
Invasive-ductal	113	53	60
Invasive-medullary	11	6	5
Other	20	4	16
Adjuvant chemotherapy	142			0.044*
None	34	10	24
Yes	108	53	55
Radiation therapy	142			0.017*
None	23	5	18
Yes	119	58	61

BRCA1-like classification with cut-off value ≥ 0.5, non-BRCA1-like classification with cut-off value < 0.5
*statistically significant with chi square test

ISSN: 1471-2407