Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study

Table 4 Association of the BRCA1-like profile with biological parameters

Variable	Valid cases	MLPA data		p-value
	(n)	BRCA1-like	Non-BRCA1-like
Total	144	63	81
BRCA1 aberrations	140			<0.000001*
Wildtype	100	28	72
Mutation/methylation	40	35	5
T-cell assessment (CD3)	53			0.458
0	17	7	10
1+	16	7	9
2+	20	12	8
PARP1 expression	52			0.087
0–2+	38	17	21
3+	14	10	4

BRCA1-like classification with cut-off value ≥ 0.5, non-BRCA1-like classification with cut-off value < 0.5
*statistically significant with chi square test

ISSN: 1471-2407