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Table 4 Association of the BRCA1-like profile with biological parameters

From: Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study

Variable Valid cases MLPA data p-value
  (n) BRCA1-like Non-BRCA1-like  
Total 144 63 81  
BRCA1 aberrations 140    <0.000001*
 Wildtype 100 28 72  
 Mutation/methylation 40 35 5  
T-cell assessment (CD3) 53    0.458
 0 17 7 10  
 1+ 16 7 9  
 2+ 20 12 8  
PARP1 expression 52    0.087
 0–2+ 38 17 21  
 3+ 14 10 4  
  1. BRCA1-like classification with cut-off value ≥ 0.5, non-BRCA1-like classification with cut-off value < 0.5
  2. *statistically significant with chi square test