Skip to main content
Fig. 2 | BMC Cancer

Fig. 2

From: Interplay of N-Cadherin and matrix metalloproteinase 9 enhances human nasopharyngeal carcinoma cell invasion

Fig. 2

PMA induced the cleavage of N-cadherin.aN-cad and MMP9 expression with/without PMA treatment. NPC cells were exposed to PMA at the indicated times, and cell lysates underwent immunoblotting. The relative band intensities of N-cadherin and MMP-9 proteins were normalized to GAPDH by densitometry. Data are mean±SEM. *P<0.05, N = 3. b PMA induced MMP-9 expression via a PKC-dependent pathway. NPC cells were pre-treated with BIM (2 μM) for 2 h, then PMA (100 nM) for 24 h. Cell lysates underwent western blot analysis with the indicated antibodies. c PMA induced the cleavage of N-cadherin. NPC cells were pre-treated with L-685,458 (5 μM, γI), then exposed to PMA for 24 h. Cell lysates underwent western blot analysis with the indicated antibodies. The ratio of FL/N-cad or CTF/N-cad to GAPDH was calculated. Data are mean±SEM. N = 3, *P<0.05

Back to article page