Fig. 3

Three-way associations among the variant, mRNA expression and the risk of developing colorectal cancer. Evidence for a genotype and phenotype associations were concluded from the two-stage case-control study. b Expression quantitative trait loci (eQTL) analyses showed the association between genotypes and mRNA expression levels. c Differential gene expression (DGE) analyses revealed the upregulated expression levels in colorectal tumor tissues than paired normal tissues. Abbreviations: OR = odds ratio; CI = confidence interval; MuTHER = Multiple Tissue Human Expression Resource; TCGA = The Cancer Genome Atlas; SYSCOL = Systems Biology of Colorectal Cancer; T / N = Tumor / Normal