Fig. 1

Regional plot of the variant rs2282151 with the P-value from discovery stage in hg19 coordinate plotted by the online tool locusZoom. Annotations on HSP90AB1 were identified using The University of California, Santa Cruz (UCSC) genome browser. The variant with the highest -log10 P value is colored purple and identified by its rs number. All other loci are represented reflecting the level of correlation with the variant. The linkage disequilibrium is estimated using Asian samples from the 1000 Genome Project. The name and location of genes in the UCSC genome browser are shown. A 10 kb window near the 5′ end of HSP90AB1 was annotated with CpG island, histone modification (H3K27ac, H3K4me3) and POLR2A peaks from multiple cell lines including HCT116 from the Encyclopedia of DNA Elements project