From: Validation of the CancerMath prognostic tool for breast cancer in Southeast Asia
 | N | Observed death in 5 years | Predicted death in 5 years | Mortality Ratio (95 % CI) | Observed 5-year survival (%)(std err) | Predicted 5-year survival (median) (%) | Absolute difference (%) (95 % CI) |
---|---|---|---|---|---|---|---|
Overall | 1538 | 286 | 173 | 1.65(1.47,1.86) | 81.4 (0.010) | 89.8 | 8.4(6.4,10.4) |
Ethnicity | |||||||
 Chinese | 1052 | 167 | 113 | 1.48(1.26,1.72) | 84.1 (0.011) | 90.4 | 6.3(4.1,8.5) |
 Malay | 264 | 62 | 30 | 2.07(1.58,2.65) | 76.5 (0.026) | 89.4 | 12.9(7.8,18.0) |
 Indian | 212 | 54 | 29 | 1.86(1.40,2.43) | 74.5 (0.030) | 87.2 | 12.7(6.8,18.6) |
 Other | 10 | 3 | 1 | 3.00(0.62,8.77) | 70.0 (0.145) | 88.2 | 18.2(−10.2,46.6) |
Period of diagnosis | |||||||
 1990–1994 | 95 | 39 | 14 | 2.79(1.98,3.81) | 58.9 (0.05) | 86.8 | 27.9 (18.1,37.7) |
 1995–1999 | 374 | 93 | 40 | 2.33(1.88,2.85) | 75.1 (0.022) | 90.9 | 15.8 (11.5,20.1) |
 2000–2003 | 568 | 91 | 63 | 1.44(1.16,1.77) | 84.0 (0.015) | 89.7 | 5.7 (2.8,8.6) |
 2004–2007 | 501 | 63 | 56 | 1.13(0.86,1.44) | 87.4 (0.015) | 90.2 | 2.8 (−0.1,5.7) |
Age at diagnosis | |||||||
 0–39 | 205 | 55 | 17 | 3.24(2.44,4.21) | 73.2 (0.031) | 92.6 | 19.4(13.3,25.5) |
 40–49 | 515 | 74 | 41 | 1.80(1.42,2.27) | 85.6 (0.015) | 92.9 | 7.3 (4.4,10.2) |
 50–59 | 449 | 86 | 50 | 1.72(1.38,2.12) | 80.8 (0.019) | 89.4 | 8.6 (4.9,12.3) |
 60–69 | 271 | 43 | 40 | 1.08(0.78,1.45) | 84.1 (0.022) | 86.1 | 2.0 (−2.3,6.3) |
 70+ | 98 | 28 | 24 | 1.17(0.78,1.69) | 71.4 (0.046) | 77.4 | 6.0 (−3.0,15.0) |
Tumor size (mm) | |||||||
 0–20 | 547 | 51 | 39 | 1.31(0.97,1.72) | 90.7 (0.012) | 94.2 | 3.5 (1.1,5.9) |
 21–50 | 813 | 170 | 102 | 1.67(1.43,1.94) | 79.1 (0.014) | 88.5 | 9.4 (6.7,12.1) |
 51+ | 178 | 65 | 32 | 2.03(1.57,2.59) | 63.5 (0.036) | 82.8 | 19.3 (12.2,26.4) |
Number of positive nodes | |||||||
 0 | 806 | 72 | 70 | 1.03(0.80,1.30) | 91.1 (0.010) | 92.4 | 1.3(−0.7,3.3) |
 1–3 | 389 | 83 | 46 | 1.80(1.44,2.24) | 78.7 (0.021) | 89.4 | 10.7(6.6,14.8) |
 4–9 | 192 | 64 | 30 | 2.13(1.64,2.72) | 66.7 (0.034) | 85.8 | 19.1(12.4,25.8) |
 10+ | 123 | 61 | 23 | 2.65(2.03,3.41) | 50.4 (0.045) | 82.3 | 31.9(23.1,40.7) |
 Unknown | 28 | 6 | 4 | 1.50(0.55,3.26) | 78.6 (0.078) | 90.6 | 12.0 (−3.3,27.3) |
ER status | |||||||
 Negative | 528 | 146 | 73 | 2.00(1.69,2.35) | 72.3 (0.019) | 87.2 | 14.9(11.2,18.6) |
 Positive | 850 | 99 | 82 | 1.21(0.98,1.47) | 88.4 (0.011) | 91.7 | 3.3 (1.1,5.5) |
 Unknown | 160 | 41 | 18 | 2.28(1.63,3.09) | 74.4 (0.035) | 89.8 | 15.4 (8.5,22.3) |
PR status | |||||||
 Negative | 423 | 106 | 57 | 1.86(1.52,2.25) | 74.9 (0.021) | 87.4 | 12.5(8.4,16.6) |
 Positive | 586 | 73 | 58 | 1.26(0.99,1.58) | 87.5 (0.014) | 91.6 | 4.1 (1.4,6.8) |
 Unknown | 529 | 107 | 58 | 1.84(1.51,2.23) | 79.8 (0.017) | 90.2 | 10.4 (7.1,13.7) |
Her2 status | |||||||
 Negative | 665 | 78 | 68 | 1.15(0.91,1.43) | 88.3 (0.012) | 91.1 | 2.8 (0.4,5.2) |
 Equivocal | 35 | 7 | 4 | 1.75(0.70,3.61) | 80.0 (0.068) | 89.9 | 9.9 (−3.4,23.2) |
 Positive | 418 | 84 | 53 | 1.58(1.26,1.96) | 79.9 (0.020) | 87.9 | 8.0 (4.1,11.9) |
 Unknown | 420 | 117 | 48 | 2.44(2.02,2.92) | 72.1 (0.022) | 89.7 | 17.6 (13.3,21.9) |
Histology | |||||||
 Ductal | 1346 | 270 | 155 | 1.74(1.54,1.96) | 79.9 (0.011) | 89.6 | 9.7 (7.5,11.9) |
 Lobular | 71 | 7 | 7 | 1.00(0.40,2.06) | 90.1 (0.035) | 91.0 | 0.9 (−6.0,7.8) |
 Mucinous | 58 | 1 | 4 | 0.25(0.01,1.39) | 98.3 (0.017) | 96.0 | −2.3 (−5.6,1.0) |
 Others | 63 | 8 | 7 | 1.14(0.49,2.25) | 88.9 (0.040) | 89.7 | 0.8 (−7.0,8.6) |
Grade | |||||||
 1 | 161 | 8 | 11 | 0.73(0.31,1.43) | 95.0 (0.017) | 95.6 | 0.6 (−2.7,3.9) |
 2 | 661 | 111 | 71 | 1.56(1.29,1.88) | 83.2 (0.015) | 90.5 | 7.3 (4.4,10.2) |
 3 | 433 | 119 | 59 | 2.02(1.67,2.41) | 72.5 (0.021) | 87.7 | 15.2 (11.1,19.3) |
 Unknown | 283 | 48 | 32 | 1.50(1.11,1.99) | 83.0 (0.022) | 89.8 | 6.8 (2.5,11.1) |
Chemo-therapy | |||||||
No chemo-therapy | 440 | 58 | 53 | 1.09(0.83,1.41) | 86.8 (0.016) | 90.4 | 3.6 (0.5,6.7) |
 1st Gen | 162 | 49 | 21 | 2.33(1.73,3.08) | 69.8 (0.036) | 88.1 | 18.3 (11.2,25.4) |
 2nd Gen | 915 | 174 | 97 | 1.79(1.54,2.08) | 81.0 (0.013) | 90.0 | 9.0 (6.5,11.5) |
 3rd Gen | 21 | 5 | 2 | 2.50(0.81,5.83) | 76.2 (0.093) | 90.8 | 14.6 (−3.6,32.8) |
Hormone-therapy | |||||||
 No | 398 | 108 | 51 | 2.12(1.74,2.56) | 72.9 (0.022) | 87.7 | 14.8 (10.5,19.1) |
 Yes | 1140 | 178 | 122 | 1.46(1.25,1.69) | 84.4 (0.011) | 90.8 | 6.4 (4.2,8.6) |