Table 3 Observed and predicted 10-year overall survival from outcome calculator, stratified by patients’ characteristics
From: Validation of the CancerMath prognostic tool for breast cancer in Southeast Asia
| Â | N | Observed death in 10Â years | Predicted death in 10Â years | Mortality Ratio (95Â % CI) | Observed 10-year survival (%)(std err) | Predicted 10-year survival (median) (%) | Absolute difference (%) (95Â % CI) |
|---|---|---|---|---|---|---|---|
Overall | 1649 | 488 | 454 | 1.07(0.98,1.17) | 70.4 (0.011) | 75.3 | 4.9 (2.7,7.1) |
 Ethnicity | |||||||
 Chinese | 1201 | 318 | 318 | 1.00(0.89,1.12) | 73.5 (0.013) | 76.8 | 3.3 (0.8,5.8) |
 Malay | 251 | 100 | 74 | 1.35(1.10,1.64) | 60.2 (0.031) | 72.3 | 12.1(6.0,18.2) |
 Indian | 174 | 64 | 55 | 1.16(0.90,1.49) | 63.2 (0.037) | 69.9 | 6.7 (−0.6,14.0) |
 Other | 23 | 6 | 7 | 0.86(0.31,1.87) | 73.9 (0.092) | 77.1 | 3.2 (−14.8,21.2) |
Country | |||||||
 Malaysia | 983 | 341 | 284 | 1.20(1.08,1.34) | 65.3 (0.015) | 73.3 | 8.0 (5.1,10.9) |
 Singapore | 666 | 147 | 170 | 0.86(0.73,1.02) | 77.9 (0.016) | 77.9 | 0.0 (−3.1,3.1) |
Period of diagnosis | |||||||
 1990–1994 | 140 | 56 | 42 | 1.33(1.01,1.73) | 60.0 (0.041) | 72.5 | 12.5(4.5,20.5) |
 1995–1999 | 564 | 187 | 148 | 1.26(1.09,1.46) | 66.8 (0.020) | 76.0 | 9.2 (5.3,13.1) |
 2000–2002 | 945 | 245 | 264 | 0.93(0.82,1.05) | 74.1 (0.014) | 75.9 | 1.8 (−0.9,4.5) |
Age at diagnosis | |||||||
 0–39 | 232 | 82 | 58 | 1.41(1.12,1.75) | 64.7 (0.031) | 77.3 | 12.6 (6.5,18.7) |
 40–49 | 576 | 137 | 130 | 1.05(0.88,1.25) | 76.2 (0.018) | 80.2 | 4.0 (0.5,7.5) |
 50–59 | 493 | 141 | 129 | 1.09(0.92,1.29) | 71.4 (0.020) | 76.4 | 5.0 (1.1,8.9) |
 60–69 | 254 | 78 | 86 | 0.91(0.72,1.13) | 69.3 (0.029) | 68.4 | −0.9 (−6.6,4.8) |
 70+ | 94 | 50 | 50 | 1.00(0.74,1.32) | 46.8 (0.051) | 50.1 | 3.3 (−6.7,13.3) |
Tumor size (mm) | |||||||
 0–20 | 653 | 118 | 109 | 1.08(0.90,1.30) | 81.9 (0.015) | 86.8 | 4.9 (2.0,7.8) |
 21–50 | 831 | 283 | 262 | 1.08(0.96,1.21) | 65.9 (0.016) | 70.6 | 4.7 (1.6,7.8) |
 51+ | 165 | 87 | 82 | 1.06(0.85,1.31) | 47.3 (0.039) | 50.6 | 3.3 (–4.3,10.9) |
Number of positive nodes | |||||||
 0 | 867 | 147 | 161 | 0.91(0.77,1.07) | 83.0 (0.013) | 84.0 | 1.0 (−1.5,3.5) |
 1–3 | 407 | 143 | 120 | 1.19(1.00,1.40) | 64.9 (0.024) | 72.1 | 7.2 (2.5,11.9) |
 4–9 | 215 | 112 | 93 | 1.20(0.99,1.45) | 47.9 (0.034) | 58.2 | 10.3 (3.6,17.0) |
 10+ | 104 | 71 | 62 | 1.15(0.89,1.44) | 31.7 (0.046) | 39.9 | 8.2 (−0.8,17.2) |
 Unknown | 56 | 15 | 17 | 0.88(0.49,1.46) | 73.2 (0.059) | 73.5 | 0.3 (−11.3,11.9) |
ER status | |||||||
 Negative | 637 | 224 | 197 | 1.14(0.99,1.30) | 64.8 (0.019) | 71.5 | 6.7 (3.0,10.4) |
 Positive | 816 | 205 | 206 | 1.00(0.86,1.14) | 74.9 (0.015) | 78.2 | 3.3 (0.4,6.2) |
 Unknown | 196 | 59 | 51 | 1.16(0.88,1.49) | 69.9 (0.033) | 76.8 | 6.9 (0.4,13.4) |
PR status | |||||||
 Negative | 485 | 160 | 153 | 1.05(0.89,1.22) | 67.0 (0.021) | 70.7 | 3.7(−0.4,7.8) |
 Positive | 564 | 128 | 136 | 0.94(0.79,1.12) | 77.3 (0.018) | 79.9 | 2.6 (−0.9,6.1) |
 Unknown | 600 | 200 | 165 | 1.21(1.05,1.39) | 66.7 (0.019) | 74.1 | 7.4 (3.7,11.1) |
Her2 status | |||||||
 Negative | 269 | 72 | 66 | 1.09(0.85,1.37) | 73.2 (0.027) | 78.3 | 5.1(−0.2,10.4) |
 Equivocal | 13 | 6 | 4 | 1.50(0.55,3.26) | 53.8 (0.138) | 65.5 | 11.7 (−15.3,38.7) |
 Positive | 335 | 113 | 110 | 1.03(0.85,1.24) | 66.3 (0.026) | 69.1 | 2.8 (−2.3,7.9) |
 Unknown | 1032 | 297 | 273 | 1.09(0.97,1.22) | 71.2 (0.014) | 76.8 | 5.6 (2.9,8.3) |
Histology | |||||||
 Ductal | 1418 | 445 | 401 | 1.11(1.01,1.22) | 68.6 (0.012) | 74.4 | 5.8 (3.4,8.2) |
 Lobular | 78 | 18 | 21 | 0.86(0.51,1.35) | 76.9 (0.048) | 75.7 | −1.2 (−10.6,8.2) |
 Mucinous | 59 | 9 | 9 | 1.00(0.46,1.90) | 84.7 (0.047) | 91.2 | 6.5 (−2.7,15.7) |
 Others | 91 | 16 | 22 | 0.73(0.42,1.18) | 82.4 (0.040) | 77.7 | −4.7 (−12.5,3.1) |
 Unknown | 3 | 0 | 1 | - | 100 | 74.4 | −25.6 |
Grade | |||||||
 1 | 200 | 22 | 31 | 0.71(0.44,1.07) | 89.0 (0.022) | 89.3 | 0.3 (−4.0,4.6) |
 2 | 668 | 188 | 176 | 1.07(0.92,1.23) | 71.9 (0.017) | 77.1 | 5.2 (1.9, 8.5) |
 3 | 510 | 196 | 172 | 1.14(0.99,1.31) | 61.6 (0.022) | 70.0 | 8.4 (4.1,12.7) |
 Unknown | 271 | 82 | 76 | 1.08(0.86,1.34) | 69.7 (0.028) | 73.3 | 3.6 (−1.9,9.1) |