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Fig. 2 | BMC Cancer

Fig. 2

From: MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines

Fig. 2

Expression of dysregulated miRNAs in canine OS. Real-time PCR was performed to independently validate changes in miRNA expression for 4 representative differentially expressed miRNAs (miR-29a, miR-126, miR-199b, miR-451) in a subset of primary canine osteoblasts cultures, osteoblast cell line (Ob, n = 5), and fresh primary canine OS tissues (OS, n = 16). Real time PCR confirmed overexpression of miR-126, miR-199b, and miR-451 and down-regulation of miR-29a expression in canine OS tumors as compared to normal canine osteoblasts (p ≤ 0.01). Three independent experiments were performed and all reactions were run in triplicate

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BMC Cancer

ISSN: 1471-2407

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