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Table 1 Clinicopathologic factors and VEGF/EGFR expression in 60 CRC patients

From: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model

Characteristics Total (N) VEGF expression P-value EGFR expression P-value
Positive Negative Positive Negative
Age (years)     0.832    0.406
  > 60 34 24 10   29 5  
  ≤ 60 26 19 7   20 6  
Gender     0.761    0.128
 Male 37 26 11   28 9  
 Female 23 17 6   21 2  
Tumor size (cm)     0.043*    0.018*
  > 5 40 32 8   36 4  
  ≤ 5 20 11 9   13 7  
Histology     0.950    0.827
 Tubular 42 30 12   34 8  
 Mucinous/Papillary 18 13 5   15 3  
Tumor location     0.890    0.982
 Colon 22 16 6   18 4  
 Rectal 38 27 11   31 7  
Differentiation status     0.101    0.027*
 Well/Moderate 44 29 15   33 11  
 Poor 16 14 2   16 0  
Hepatic metastasis     0.005*    0.034*
 Absent 45 28 17   34 11  
 Present 15 15 0   15 0  
TNM stage     0.037*    0.012*
 I-II 41 26 15   30 11  
 III-IV 19 17 2   19 0  
  1. Note: *P < 0.05
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