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Table 1 Clinicopathologic factors and VEGF/EGFR expression in 60 CRC patients

From: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model

Characteristics

Total (N)

VEGF expression

P-value

EGFR expression

P-value

Positive

Negative

Positive

Negative

Age (years)

   

0.832

  

0.406

  > 60

34

24

10

 

29

5

 

  ≤ 60

26

19

7

 

20

6

 

Gender

   

0.761

  

0.128

 Male

37

26

11

 

28

9

 

 Female

23

17

6

 

21

2

 

Tumor size (cm)

   

0.043*

  

0.018*

  > 5

40

32

8

 

36

4

 

  ≤ 5

20

11

9

 

13

7

 

Histology

   

0.950

  

0.827

 Tubular

42

30

12

 

34

8

 

 Mucinous/Papillary

18

13

5

 

15

3

 

Tumor location

   

0.890

  

0.982

 Colon

22

16

6

 

18

4

 

 Rectal

38

27

11

 

31

7

 

Differentiation status

   

0.101

  

0.027*

 Well/Moderate

44

29

15

 

33

11

 

 Poor

16

14

2

 

16

0

 

Hepatic metastasis

   

0.005*

  

0.034*

 Absent

45

28

17

 

34

11

 

 Present

15

15

0

 

15

0

 

TNM stage

   

0.037*

  

0.012*

 I-II

41

26

15

 

30

11

 

 III-IV

19

17

2

 

19

0

 
  1. Note: *P < 0.05
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BMC Cancer

ISSN: 1471-2407

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