TY - JOUR AU - Liu, Tao AU - Wang, Gang AU - Tao, Huangheng AU - Yang, Zhonghua AU - Wang, Yongzhi AU - Meng, Zhe AU - Cao, Rui AU - Xiao, Yu AU - Wang, Xinghuan AU - Zhou, Jiajie PY - 2016 DA - 2016/10/12 TI - Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma JO - BMC Cancer SP - 790 VL - 16 IS - 1 AB - Renal cell carcinoma (RCC) is one of the tumors most refractory to chemotherapy to date. Therefore, novel therapeutic agents are urgently needed for this disease. Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers. Nonetheless, the anti-cancer activity of CPS has never been studied in human RCC. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-016-2831-y DO - 10.1186/s12885-016-2831-y ID - Liu2016 ER -