Intrahepatic cholangiocarcinoma prognostic determination using pre-operative serum C-reactive protein levels

BMC Cancer

Table 3 Cox multivariate analyses of prognostic factors on patients’ survival

Variables	Hazards ratio	95 % CI	P value
Cancer-specific survival^a
CA19-9, U/ml (≤35 v >35)	1.553	0.904–2.668	0.111
Tumor size, cm (≤5.5 v >5.5)	2.143	1.239–3.706	0.006
Nodal metastasis (absent v present)	1.390	0.703–2.749	0.343
Vascular invasion (absent v present)	1.954	1.181–3.233	0.009
TNM (I-II v III-IV)	0.884	0.459–1.702	0.711
Serum CRP, mg/L (≤1.8 v >1.8)	2.646	1.356–5.164	0.004
Recurrence- free survival^b
Postoperative chemotherapy (yes v no)	1.788	1.042–3.067	0.035
Tumor size, cm (≤5.5 v >5.5)	1.920	1.153–3.197	0.012
Nodal metastasis (absent v present)	1.277	0.689–2.367	0.437
Vascular invasion (absent v present)	1.733	1.107–2.715	0.016
TNM (I-II v III-IV)	0.663	0.369–1.191	0.169
Serum CRP, mg/L (≤1.8 v >1.8)	2.827	1.636–4.886	< 0.001

CI confidence interval, CA19-9 carbohydrate antigen 19-9, TNM tumor-node-metastasis, CRP C-reactive protein
^aThe total number of patients and total number of events in this model were 140 and 67, respectively
^bThe total number of patients and total number of events in this model were 140 and 87, respectively

ISSN: 1471-2407