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Table 2 Univariate analyses of serum C-reactive protein (CRP) levels and clinicopathologic variables in 140 patients with intrahepatic cholangiocarcinoma (Cox proportional-hazards regression)

From: Intrahepatic cholangiocarcinoma prognostic determination using pre-operative serum C-reactive protein levels

Variables

All cases

Cancer-specific survival

Recurrence-free survival

Hazard Ratio (95 % CI)

P value

Hazard Ratio (95 % CI)

P value

Age (years)

  ≤ 55a

75

1

 

1

 

  > 55

65

0.930 (0.572–1.513)

0.772

0.862 (0.562–1.321)

0.496

Gender

 Male

93

1

 

1

 

 Female

47

0.770 (0.455–1.301)

0.329

0.770 (0.488–1.214)

0.216

Location

 Right lobe

75

1

 

1

 

 Left lobe

46

1.329 (0.772–2.289)

0.304

1.224 (0.760–1.972)

0.407

 Both lobes or quadrate lobe

19

1.192 (0.855–1.662)

0.300

1.217 (0.900–1.646)

0.202

ALT

 Normal

87

1

 

1

 

 Elevated

53

1.295 (0.794–2.110)

0.300

1.218 (0.791–1.874)

0.371

AST

 Normal

97

1

 

1

 

 Elevated

43

1.305 (0.783–2.175)

0.308

1.149 (0.729–1.812)

0.550

HbsAg

 Positive

55

1.027 (0.629–1.675)

0.916

1.212 (0.785–1.871)

0.385

 Negative

82

1

 

1

 

Tumor size (cm)

  ≤ 5.5b

71

1

 

1

 

  > 5.5

69

2.315 (1.407–3.810)

0.001

2.072 (1.347–3.188)

0.001

Grade

 I

14

1

 

1

 

 II

77

0.490 (0.169–1.418)

0.188

0.363 (0.141–0.934)

0.036

 III

49

0.910 (0.544–1.521)

0.719

0.794 (0.507–1.244)

0.314

Nodal metastasis

 No

111

1

 

1

 

 Yes

29

2.048 (1.169–3.589)

0. 011

1.847 (1.123–3.038)

0. 016

Tumor multiplicity

 Single

108

1

 

1

 

 Multiple

32

1.266 (0.729–2.198)

0.403

1.214 (0.742–1.985)

0.440

Intraepithelial ductal spread

 Absent

52

0.821 (0.507–1.329)

0.422

0.897 (0.585–1.375)

0.618

 Present

88

1

 

1

 

Vascular invasion

 Absent

86

1

 

1

 

 Present

54

2.298 (1.416–3.731)

0.001

1.901 (1.238–2.918)

0.003

TNM

 I-II

78

1

 

1

 

 III-IV

62

1.977 (1.203–3.249)

0.007

1.644 (1.065–2.536)

0.025

CEA (ng/ml)

  ≤ 5

101

1

 

1

 

  > 5

38

1.276 (0.734–2.219)

0.388

1.317 (0.819–2.119)

0.255

CA19-9 (U/ml)

  ≤ 35

57

1

 

1

 

  > 35

82

1.889 (1.125–3.169)

0.016

1.441 (0.930–2.234)

0.102

Postoperative chemotherapy

 No

93

1

 

1

 

 Yes

47

1.520 (0.925–2.498)

0.098

2.515 (1.619–3.908)

<0.001

Serum CRP (mg/L)

  ≤ 1.8

42

1

 

1

 

  > 1.8

98

2.965 (1.551–5.667)

0.001

2.751

<0.001

  1. ALT alanine aminotransferase, AST aspartate aminotransferase, HbsAg hepatitis B surface antigen, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, TNM tumor-node-metastasis
  2. aMedian age
  3. bMedian size
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