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Table 1 Correlation of preoperative serum C-reactive protein levels with patients’ clinico-pathological features in intra-hepatic cholangiocarcinoma

From: Intrahepatic cholangiocarcinoma prognostic determination using pre-operative serum C-reactive protein levels

Variable

All cases

Serum CRP mg/L

P valuea

≤1.8

> 1.8

Age (years)

   

0.355

  ≤ 55b

75

21 (28.0 %)

54 (72.0 %)

 

  > 55

71

21 (32.3 %)

44 (67.7 %)

 

Gender

   

0.018

 Male

93

22 (23.7 %)

71 (76.3 %)

 

 Female

47

20 (42.6 %)

27 (57.4 %)

 

Location

   

0.263

 Right lobe

75

26 (34.7 %)

49 (65.3 %)

 

 Left lobe

46

13 (28.3 %)

33 (71.7 %)

 

Both lobes or quadrate lobe

19

3 (15.8 %)

16 (84.2 %)

 

 ALT

   

< 0.001

 Normal

87

37 (42.5 %)

50 (57.5 %)

 

 Elevated

53

5 (9.4 %)

48 (90.6 %)

 

AST

   

0.002

 Normal

97

37 (38.1 %)

60 (61.9 %)

 

 Elevated

43

5 (11.6 %)

38 (88.4 %)

 

HbsAg

   

0.417

 Positive

55

15 (27.3 %)

40 (72.7 %)

 

 Negative

82

25 (30.5 %)

57 (69.5 %)

 

CEA (ng/ml)

   

0.047

  ≤ 5

101

35 (34.7 %)

66 (65.3 %)

 

  > 5

38

7 (16.7 %)

31 (81.6 %)

 

CA19-9 (U/ml)

   

0.024

  ≤ 35

57

23 (40.4 %)

34 (59.6 %)

 

  > 35

82

19 (23.2 %)

63 (76.8 %)

 

Tumor size (cm)

   

0.119

  ≤ 5.5c

71

25 (35.2 %)

46 (64.8 %)

 

  > 5.5

69

17 (24.6 %)

52 (75.4 %)

 

Nodal metastasis

   

0.158

 Yes

29

6 (20.7 %)

23 (79.3 %)

 

 No

111

36 (32.4 %)

75 (67.6 %)

 

Tumor multiplicity

   

0.830

 Single

108

32 (29.6 %)

76 (70.4 %)

 

 Multiple

32

10 (31.2 %)

22 (68.8 %)

 

Intraepithelial ductal spread

   

0.039

 Absent

52

21 (40.4 %)

31 (59.6 %)

 

 Present

88

21 (23.9 %)

67 (76.1 %)

 

Vascular invasion

   

0.940

 Absent

86

26 (30.2 %)

60 (69.8 %)

 

 Present

54

16 (29.6 %)

38 (70.4 %)

 

Grade

   

0.185

 I

14

7 (50.0 %)

7 (50.0 %)

 

 II

77

23 (29.9 %)

31 (70.1 %)

 

 III

49

12 (24.5 %)

37 (75.5 %)

 

TNM

   

0.011

 I-II

78

30 (38.5 %)

48 (61.5 %)

 

 III- IV

62

12 (19.4 %)

50 (80.6 %)

 

Postoperative chemotherapy

   

0.078

 Yes

47

10 (21.3 %)

37 (78.7 %)

 

 No

93

32 (34.4 %)

61 (65.6 %)

 
  1. aChi-square test
  2. bMedian age
  3. cMedian size
  4. CRP C-reactive protein, ALT alanine aminotransferase, AST aspartate aminotransferase, HbsAg hepatitis B surface antigen, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, TNM tumor-node-metastasis