Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma

BMC Cancer

Table 1 Clinical-pathological characteristics of studied groups of patients

Characteristics	Testing set	Validation set I	Validation set II
	(n = 52)	(n = 67)	(n = 32)
Gender (male/female)	36/16	45/22	19/13
Age at diagnosis^a	63.9 ± 9.2 years	70.2 ± 9.5 years	70.8 ± 11.2 years
Tumor size (pT)
pT2	3	-	4
pT3	40	62	24
pT4	9	5	4
Presence of lymph node metastasis (pN)
pN0	15	67	18
pN1-2	37	-	14
Presence of distant metastasis (pM)
pM0	26	67	32
pM1	26	-	-
Stage
UICC II	8	67	18
UICC III	18	-	14
UICC IV	26	-	-
Histological grade (G)^b
GI	6	9	6
GII	39	47	19
GIII	7	8	3
Gx	-	3	4
Primary localization
Colon	26	44	28
Rectosigmoideum	12	9	1
Rectum	14	14	3
Chemotherapy
5-FU-based	52	24^c	17
None	-	33^c	15

Footnotes:
^aMedian ± standard deviation
^b GI well differentiated, GII moderately differentiated, GIII poorly differentiated, Gx cannot be assessed
^cNumbers may not add up to 67 of available subjects because of missing data (n = 10)

ISSN: 1471-2407