Table 3 Target genes and miRNAs from Metabolic pathways, MAP kinase, Cell Adhesion and Immune Response category groups showing inverse correlation in LLC1 cells after 48Â h growth between 2D and lr-ECM 3D cell culture conditions
Category | Up-regulated genes | Down-regulated miRNAs | Down-regulated genes | Up-regulated miRNAs |
|---|---|---|---|---|
Metabolic pathways | Agpat3↑ Cyp4f18↑ | miR-19a-5p↓ | B3gat1↓ | miR-669b-5p↑ |
Akr1b7↑ | miR-137-3p↓ | Dhrs9↓ | miR-297a-3p↑; miR-466b-3p↑; miR-466d-3p↑ | |
B3galt6↑ Dtymk↑ | miR-495-3p↓ | Kynu↓ | miR-672-5p↑ | |
Ctps↑ | miR-544-3p↓ | Ocrl↓ | miR-466 g↑ | |
Dgkb↑ | miR-9-5p↓; miR-590-3p↓; miR-126-5p↓ | Pla2g2c↓ | miR-468-3p↑ | |
Ext1↑ | miR-19a-5p↓; miR-590-3p↓; miR-9-5p↓; miR-135a-5p↓ | Ppt1↓ | miR-346-5p↑ | |
Man2a1↑ | miR-135a-5p↓; miR-495-3p↓ | Sc5d↓ | miR-669b-5p↑ | |
Pigm↑ | miR-9-5p↓; miR-495-3p↓; miR-590-3p↓ |  |  | |
MAPK kinase | Cacna1d ↑ | miR-137-3p↓; miR-448-3p↓; miR-495-3p↓ | Kras↓ | miR-761↑ |
Ikbkg ↑ | miR-137-3p↓ | Mknk1↓ | miR-195-5p↑ | |
Traf6↑ | miR-590-3p↓ | Pak2↓ | miR-297a-3p↑ | |
|  |  | Sos2↓ | miR-34b-3p↑; miR-34c-3p↑; miR-466f-3p↑; miR-500-3p↑ | |
Cell adhesion | Arhgef4↑ | miR-135a-5p↓; miR-448-3p↓; miR-200b-3p↓; miR-20b-3p↓ | Tmsb4x↓ | miR-448↑ |
Col1a1↑ | miR-135a-5p↓; miR-137↓; miR-590↓ | Flna↓ | miR-328-3p; miR-761↑ | |
Itpr1↑ | miR-544-3p↓ | Gnas↓ | miR-877-3p↑ | |
Pard3↑ | miR-495-3p↓ | Htr2c↓ | miR-466d-3p↑ | |
Slc9a1↑ | miR-9-5p↓ | Pak2↓ | miR-297a-3p↑ | |
Vegfa ↑ | miR-1a↓ | Pak3↓ | miR-297a-3p↑ | |
|  |  | Rhoa↓ | miR-466f-3p↑ | |
|  |  | Ssh1↓ | miR-467b↑ | |
Immune resopnse | Pard3↑ | miR-495-3p↓ | Eif2ak1↓ | miR-500-3p↑ |
|  |  | Oas3↓ | miR-297a-3p↑; miR-466b-3p↑; miR-466d-3p↑; miR-466f-3p↑; miR-466 g↑; miR-467d-3p↑; miR-467e-3p↑ | |
|  |  | Ppp2r1b↓ | miR-195-5p↑; miR-672-5p↑ | |
|  |  | Ppp2r2b↓ | miR-466 g↑ | |
|  |  | Xcr1↓ | miR-669b↑ |