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Table 3 Health economic analysis

From: SAKK 24/09: safety and tolerability of bevacizumab plus paclitaxel vs. bevacizumab plus metronomic cyclophosphamide and capecitabine as first-line therapy in patients with HER2-negative advanced stage breast cancer - a multicenter, randomized phase III trial

 

Mean

95 % CI for mean

Median

SD

Arm A: Bevacizumab + paclitaxel (N = 66)

 TTS, months

7.3

6.3–8.2

5.9

4.0

 Utility

0.8

0.7–0.8

0.8

0.2

 QALM

5.9

5.0–6.8

5.1

3.7

 Total incurred costs, CHF

69,474

60,624–78,324

61,815

36,001

 Costs per month, CHF

10,044

9,216–10,871

9,385

3,367

 Costs per QALM

14,389

11,955–16,823

11,249

9,900

Arm B: Bevacizumab + capecitabine + cyclophosphamide (N = 63)

 TTS, months

8.5

6.7–10.2

6.8

7.0

 Utility

0.7

0.7–0.8

0.7

0.2

 QALM

6.5

5.0–8.1

5.0

6.3

 Total incurred costs, CHF

80,324

62,975–97,672

61,751

68,885

 Costs per month, CHF

10,229

9,317–11,142

9,158

3,622

 Costs per QALM

40,826

−7,257–88,909

12,025

190,922

  1. N number of patients, TTS time to treatment stop, QALM quality adjusted life month, CHF swiss francs, CI confidence interval, SD standard deviation of the mean
  2. Unit costs for the health economics analysis are provided in the Additional file 1: Table S1