Fig. 3
From: Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma
NB cell lines and PDX tumors display various ALDH isoenzyme expression patterns. a Basal endogenous mRNA expression levels of each ALDH1 isoform were measured in 10 NB cell lines (* = serum-free medium) and 3 NB PDX tumors by real-time PCR. Mean ratio of ALDH1 isoform/HPRT1 ± SD are plotted in the bar graphs. Experiments were performed in tri- or quadruplicates (nd: not detected). b Comparison of ALDH1A1/A2/A3 mRNA expression levels between S-type versus N/I-type cell lines (left panel) and NB cell lines versus PDX tumors (right panel). Individual values and mean values ± SD of ALDH1 isoform/HPRT1 ratio are plotted in the dot plots (Mann Whithney test *p = 0.033, **p = 0.007)