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Table 5 Univariate and multivariate analysis of prognostic factors

From: Comparison of different methods of splenic hilar lymph node dissection for advanced upper- and/or middle-third gastric cancer

 

Univariate HR (95 % CI)

Pvalue

Multivariate HR (95 % CI)

Pvalue

Gender

 

0.679

  

 Male

1

   

 Female

0.909(0.580,1.427)

   

Age

 

0.254

  

  < 60

1

   

  ≥ 60

1.238(0.857,1.788)

   

BMI

 

0.287

  

  < 19

1

   

  ~ <25

0.578(0.307,1.090)

0.090

  

  ~ <30

0.496(0.241,1.020)

0.057

  

  ≥ 30

0.635(0.140,2.873)

0.555

  

 Postoperative hospital stay

1.010(0.995,1.026)

0.205

  

Reoperation

 

0.899

  

 No

1

   

 Yes

1.067(0.393,2.896)

   

Location

 

0.100

  

 EGJ

1

   

 U/UM

0.991(0.519,1.895)

0.979

  

 MU/M

1.394(0.937,2.074)

0.101

  

 EUM

2.908(1.048,8.071)

0.040

  

Degree of LND

 

0.701

  

 D1+

1

   

 D2

1.286(0.562,2.942)

0.551

  

 D2+

1.082(0.426,2.747)

0.868

  

SHLN dissection method

 

0.020

 

0.061

 In situ

1

 

1

 

 Ex situ

0.822(0.541,1.249)

0.369

0.804(0.510,1.269)

0.349

 Splenectomy

1.671(0.983,2.840)

0.058

1.522(0.865,2.678)

0.145

 Operation duration

1.005(1.003,1.007)

<0.001

1.003(1.000,1.005)

0.043

 Blood loss volume

1.001(1.001,1.002)

<0.001

1.001(1.000,1.002)

0.046

Postoperative complications

 

0.036

 

0.468

 No

1

 

1

 

 Yes

1.607(1.030,2.507)

 

1.210(0.723,2.027)

 

NACT

 

0.007

 

0.005

 No

1

 

1

 

 Yes

1.689(1.157,2.466)

 

2.289(1.501,3.492)

 

Multi-tumor

 

0.011

 

0.099

 No

1

 

1

 

 Yes

3.203(1.301,7.887)

 

2.402(0.849,6.800)

 

Differentiation

 

0.039

 

0.319

 Well

1

 

1

 

 Moderate

1.200(0.512,2.816)

0.674

1.155(0.474,2.818)

0.751

 Poor

1.886(0.816,4.361)

0.138

1.550(0.643,3.734)

0.329

Tumor size

 

0.007

 

0.135

  ≤ 2 cm

1

 

1

 

  ~ ≤5 cm

3.075(1.110,8.524)

0.031

2.931(0.877,9.794)

0.081

  ~ ≤10 cm

4.227(1.520,11.754)

0.006

3.420(0.989,11.828)

0.052

  > 10 cm

5.702(1.888,17.220)

0.002

4.710(1.254,17.684)

0.022

T stagea

 

0.040

 

0.572

 Serosa negative

1

 

1

 

 T4a

1.728(0.872,3.428)

0.117

1.541(0.651,3.652)

0.326

 T4b

3.036(1.275,7.227)

0.012

1.645(0.604,4.482)

0.330

N stagea

 

<0.001

 

<0.001

 N0

1

 

1

 

 N1

1.482(0.755,2.908)

0.253

1.398(0.696,2.808)

0.347

 N2

1.937(1.308,3.616)

0.038

1.836(0.933,3.609)

0.078

 N3a

1.714(0.904,3.250)

0.099

1.958(0.988,3.883)

0.054

 N3b

5.441(2.950,10.033)

<0.001

6.327(3.181,12.582)

<0.001

LVI

 

0.004

 

0.334

 No

1

 

1

 

 Yes

1.727(1.182,2.523)

 

1.299(0.764,2.209)

 

Gastrectomy

 

0.001

 

0.203

 Proximal

1

 

1

 

 Total

2.098(1.336,3.224)

 

1.368(0.844,2.218)

 
  1. BMI body mass index, EGJ esophagogastric junction, E esophagus, U upper, M middle, LND lymph node dissection, SHLN splenic hilar lymph node, NACT neoadjuvant chemotherapy, LVI lymphovascular invasion
  2. a7th UICC/AJCC TNM classification for gastric cancer