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Table 5 Univariate and multivariate analysis of prognostic factors

From: Comparison of different methods of splenic hilar lymph node dissection for advanced upper- and/or middle-third gastric cancer

  Univariate HR (95 % CI) Pvalue Multivariate HR (95 % CI) Pvalue
Gender   0.679   
 Male 1    
 Female 0.909(0.580,1.427)    
Age   0.254   
  < 60 1    
  ≥ 60 1.238(0.857,1.788)    
BMI   0.287   
  < 19 1    
  ~ <25 0.578(0.307,1.090) 0.090   
  ~ <30 0.496(0.241,1.020) 0.057   
  ≥ 30 0.635(0.140,2.873) 0.555   
 Postoperative hospital stay 1.010(0.995,1.026) 0.205   
Reoperation   0.899   
 No 1    
 Yes 1.067(0.393,2.896)    
Location   0.100   
 EGJ 1    
 U/UM 0.991(0.519,1.895) 0.979   
 MU/M 1.394(0.937,2.074) 0.101   
 EUM 2.908(1.048,8.071) 0.040   
Degree of LND   0.701   
 D1+ 1    
 D2 1.286(0.562,2.942) 0.551   
 D2+ 1.082(0.426,2.747) 0.868   
SHLN dissection method   0.020   0.061
 In situ 1   1  
 Ex situ 0.822(0.541,1.249) 0.369 0.804(0.510,1.269) 0.349
 Splenectomy 1.671(0.983,2.840) 0.058 1.522(0.865,2.678) 0.145
 Operation duration 1.005(1.003,1.007) <0.001 1.003(1.000,1.005) 0.043
 Blood loss volume 1.001(1.001,1.002) <0.001 1.001(1.000,1.002) 0.046
Postoperative complications   0.036   0.468
 No 1   1  
 Yes 1.607(1.030,2.507)   1.210(0.723,2.027)  
NACT   0.007   0.005
 No 1   1  
 Yes 1.689(1.157,2.466)   2.289(1.501,3.492)  
Multi-tumor   0.011   0.099
 No 1   1  
 Yes 3.203(1.301,7.887)   2.402(0.849,6.800)  
Differentiation   0.039   0.319
 Well 1   1  
 Moderate 1.200(0.512,2.816) 0.674 1.155(0.474,2.818) 0.751
 Poor 1.886(0.816,4.361) 0.138 1.550(0.643,3.734) 0.329
Tumor size   0.007   0.135
  ≤ 2 cm 1   1  
  ~ ≤5 cm 3.075(1.110,8.524) 0.031 2.931(0.877,9.794) 0.081
  ~ ≤10 cm 4.227(1.520,11.754) 0.006 3.420(0.989,11.828) 0.052
  > 10 cm 5.702(1.888,17.220) 0.002 4.710(1.254,17.684) 0.022
T stagea   0.040   0.572
 Serosa negative 1   1  
 T4a 1.728(0.872,3.428) 0.117 1.541(0.651,3.652) 0.326
 T4b 3.036(1.275,7.227) 0.012 1.645(0.604,4.482) 0.330
N stagea   <0.001   <0.001
 N0 1   1  
 N1 1.482(0.755,2.908) 0.253 1.398(0.696,2.808) 0.347
 N2 1.937(1.308,3.616) 0.038 1.836(0.933,3.609) 0.078
 N3a 1.714(0.904,3.250) 0.099 1.958(0.988,3.883) 0.054
 N3b 5.441(2.950,10.033) <0.001 6.327(3.181,12.582) <0.001
LVI   0.004   0.334
 No 1   1  
 Yes 1.727(1.182,2.523)   1.299(0.764,2.209)  
Gastrectomy   0.001   0.203
 Proximal 1   1  
 Total 2.098(1.336,3.224)   1.368(0.844,2.218)  
  1. BMI body mass index, EGJ esophagogastric junction, E esophagus, U upper, M middle, LND lymph node dissection, SHLN splenic hilar lymph node, NACT neoadjuvant chemotherapy, LVI lymphovascular invasion
  2. a7th UICC/AJCC TNM classification for gastric cancer