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Table 1 Univariable associations of physician receptivity to genomic risk assessment (GUCY2C) for pN0 colon cancer patients

From: A survey of physician receptivity to molecular diagnostic testing and readiness to act on results for early-stage colon cancer patients

  Total (n = 41) Receptive (n = 22) Not Receptive (n = 19) p-value
n (%) n (%) n (%)
Practice Environment:
 Practice Setting     0.004
  Community-based or Other 24 (58.54) 8 (33.33) 16 (66.67) .
  Academic Center-based 17 (41.46) 14 (82.35) 3 (17.65) .
Sociodemographic Background and Experience:
 Age     1.000
  <50 21 (51.22) 11 (52.38) 10 (47.62) .
  50+ 20 (48.78) 11 (55.00) 9 (45.00) .
 Gender     0.219
  Male 34 (82.93) 20 (58.82) 14 (41.18) .
  Female 7 (17.07) 2 (28.57) 5 (71.43) .
 Race     1.000
  (missing/unknown) 1 (.) 0 (.) 1 (.) .
  Asian 13 (32.50) 7 (53.85) 6 (46.15) .
  White 27 (67.50) 15 (55.56) 12 (44.44) .
 Hispanic/Latino     0.463
  No 40 (97.56) 22 (55.00) 18 (45.00) .
  Yes 1 (2.44)   1 (100.0) .
 Years in Practice     0.891
  < =10 4 (9.76) 2 (50.00) 2 (50.00) .
  10–20 11 (26.83) 5 (45.45) 6 (54.55) .
  >20 26 (63.41) 15 (57.69) 11 (42.31) .
 Specialty     0.758
  Medical Oncologists+ 23 (56.10) 13 (56.52) 10 (43.48) .
  GI Surgeons 18 (43.90) 9 (50.00) 9 (50.00) .
 Number of newly diagnosed pN0 colon cancer patients seen in past 12 months     0.668
  <5 6 (14.63) 4 (66.67) 2 (33.33) .
  5+ 35 (85.37) 18 (51.43) 17 (48.57) .
 Percentage of pN0 colon cancer patients who have had a recurrence in the past 12 months     1.000
  None 20 (48.78) 11 (55.00) 9 (45.00) .
  1+ 21 (51.22) 11 (52.38) 10 (47.62) .
 On average how many pN0 colon cancer patients do you see each month?     0.737
  <5 28 (68.29) 16 (57.14) 12 (42.86) .
  5+ 13 (31.71) 6 (46.15) 7 (53.85) .
Perceptions about Diagnostic/Prognostic Testing:
 Belief in accuracy of histopathology     1.000
  Not Agree 14 (34.15) 8 (57.14) 6 (42.86) .
  Agree 27 (65.85) 14 (51.85) 13 (48.15) .
 Belief in accuracy of GUY2C testing     0.216
  Not Agree 17 (41.46) 7 (41.18) 10 (58.82) .
  Agree 24 (58.54) 15 (62.50) 9 (37.50) .
 Belief in accuracy of combined histopathology and GUCY2C testing     0.038
  Not Agree 4 (9.76) 0 (0.0) 4 (100.0) .
  Agree 37 (90.24) 22 (59.46) 15 (40.54) .
 Belief in need for a more accurate prognostic test for pN0 colon cancer patients     1.000
  Not Agree 2 (4.88) 1 (50.00) 1 (50.00) .
  Agree 39 (95.12) 21 (53.85) 18 (46.15) .
 Belief that current staging methods are not accurate for pN0 colon cancer patients     0.216
  Not Agree 17 (41.46) 7 (41.18) 10 (58.82) .
  Agree 24 (58.54) 15 (62.50) 9 (37.50) .
 Accuracy of histopathology alone     0.388
  (missing/unknown) 1 (.) 0 (.) 1 (.) .
  Very Accurate 6 (15.00) 3 (50.00) 3 (50.00) .
  Somewhat Accurate 31 (77.50) 16 (51.61) 15 (48.39) .
  Not Accurate 3 (7.50) 3 (100.0) 0 (0.0) .
  Don’t know 0 (0.0) 0 (0.0) 0 (0.0) .
 Accuracy of GUCY2C testing alone     0.133
  (missing/unknown) 2 (.) 0 (.) 2 (.) .
  Very Accurate 6 (15.38) 4 (66.67) 2 (33.33) .
  Somewhat Accurate 22 (56.41) 13 (59.09) 9 (40.91) .
  Not Accurate 3 (7.69) 3 (100.0) 0 (0.0) .
  Don’t Know 8 (20.51) 2 (25.00) 6 (75.00) .
 Accuracy of combined histopathology and GUCY2C testing     0.054
  (missing/unknown) 1 (.) 0 (.) 1 (.) .
  Very Accurate 25 (62.50) 16 (64.00) 9 (36.00) .
  Somewhat Accurate 11 (27.50) 6 (54.55) 5 (45.45) .
  Not Accurate 0 (0.0) 0 (0.0) 0 (0.0)  
  Don’t Know 4 (10.00) 0 (0.0) 4 (100.0) .
Perceptions about Treatment:
 Stress from uncertainty in decision making about treatment for pN0 colon cancer patients (scale)     0.350
  Not Agree (<=3) 22 (53.66) 10 (45.45) 12 (54.55) .
  Agree (>3) 19 (46.34) 12 (63.16) 7 (36.84) .
 Belief that treatment decision making for pN0 colon cancer patients is easy     0.009
  Not Agree 13 (31.71) 11 (84.62) 2 (15.38) .
  Agree 28 (68.29) 11 (39.29) 17 (60.71) .
 Confidence in treatment decision making for pN0 colon cancer patients     0.325
  Not Agree 12 (29.27) 8 (66.67) 4 (33.33) .
  Agree 29 (70.73) 14 (48.28) 15 (51.72) .
 Belief that treatment choice for pN0 colon cancer patients is clear     0.756
  Not Agree 19 (46.34) 11 (57.89) 8 (42.11) .
  Agree 22 (53.66) 11 (50.00) 11 (50.00) .