Fig. 2

Impacted metabolic pathways and changed metabolites in tumour-bearing rats (W and LW groups) compared to non-tumour-bearing animals (C and L groups). a Summary of significantly impacted pathways (P ≤ 0.05) analysed by the different metabolites found in the leucine group in comparison to the C group. b Comparison of tumour-bearing rats fed with normal diet (W) and the C group with a serum list of increased and decreased metabolites levels in W group. Metabolite set enrichment analysis revealed the affected pathways. c Comparison of tumour-bearing rats (LW) and non-tumour-bearing rats (L) fed a leucine-rich diet with a list of serum metabolites, which both increased and decreased in the LW group serum. Metabolite set enrichment analysis revealed the affected pathways. d Comparison between both tumour-bearing rats fed a normal diet (W) and a leucine-rich diet (LW) with a list of metabolites that increased and decreased in the LW serum compared to the W serum. All data were processed using the Metaboanalyst tool [39]. For details, see Methods