TY - JOUR AU - Yedid, Nofar AU - Kalma, Yael AU - Malcov, Mira AU - Amit, Ami AU - Kariv, Revital AU - Caspi, Michal AU - Rosin-Arbesfeld, Rina AU - Ben-Yosef, Dalit PY - 2016 DA - 2016/12/23 TI - The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells JO - BMC Cancer SP - 952 VL - 16 IS - 1 AB - Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inherit a germline mutation in one APC allele, and loss of the second allele leads to the development of polyps that will turn malignant if not removed. It is not fully understood which molecular mechanisms are activated by APC loss and when the loss of the second APC allele occurs. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-016-2809-9 DO - 10.1186/s12885-016-2809-9 ID - Yedid2016 ER -