Skip to main content
Fig. 1 | BMC Cancer

Fig. 1

From: Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes.

Fig. 1

Salivary 17 β -estradiol levels across menstrual cycles for rs3020364, rs2474148, rs2982712. All analyses have used linear mixed models for repeated measures adjusted for age, age at menarche, parity, body mass index, current smoking and previous oral contraceptives. 95 % confidence intervals were removed for clarity. aa = minor homozygous genotype, Aa = heterozygous genotype, AA = major homozygous genotype. Mean 17β-estradiol levels by genotypes: a rs3020364 and low percent mammographic density (<28.5 %): aa (n = 23);14.0 pmol/L, Aa(n = 44); 19.2 pmol/L, AA(n = 28); 18.5. b rs3020364 and high percent mammographic density (≥28.5 %): aa (n = 21);29.0 pmol/L, Aa(n = 41); 18.7 pmol/L, AA(n = 45); 18.3. c rs2474148 and low percent mammographic density (<28.5 %): aa (n = 21);14.0 pmol/L, Aa(n = 44); 19.1 pmol/L, AA(n = 30); 18.4. d rs2474148 and high percent mammographic density (≥28.5 %): aa (n = 5);28.4 pmol/L, Aa(n = 35); 18.2 pmol/L, AA(n = 51); 18.5. e rs2982712 and low percent mammographic density (<28.5 %): aa (n = 31);15.1 pmol/L, Aa(n = 42); 19.4pmol/L, AA(n = 22); 18.4. f rs2982712 and high percent mammographic density (≥28.5 %): aa (n = 10);25.9 pmol/L, Aa(n = 50); 17.4 pmol/L, AA(n = 31); 19.2

Back to article page