Fig. 4

Effects of miR-10b on HCC cell migration and invasion. HepG2 cells were transfected with hsa-miR-10b mimics (10b-m), mimics negative control (mnc), hsa-miR-10b inhibitors (10b-i), or inhibitors negative control (inc). a Transwell migration assay. miR-10b mimics led to a 2-fold increase in cell migration, whereas knockdown of miR-10b reduced migration by 40 %. b Matrigel invasion assay. miR-10b mimics led to over 50 % increase in cell invasion capacity, whereas knockdown of miR-10b reduced invasion by 40 %. c Wound healing assay. miR-10b mimics induced wound healing at 48 h, while the mnc group did not demonstrated wound healing at 72 h. miR-10b inhibitors and inc did not induce wound healing at 72 h, but the inc group demonstrated better wound healing compared to the inhibitors