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Table 4 Odds ratios per 5 kg/m2 increase of BMI at age 20, BMI at age 50, current BMI and BMI changes stratified by BMI at age 20, current age and current MHT use

From: Weight and weight changes throughout life and postmenopausal breast cancer risk: a case-control study in France

  BMI at age 20 < 18.5 kg/m2 BMI at age 20 ≥ 18.5 kg/m2 p interaction
  (146 cases / 150 controls) (574 cases / 641 controls)
  ORa 95 % CI p trendb ORa 95 % CI p trendb
BMI at age 50 1.36 [0.88-2.01] 0.16 1.08 [0.93-1.25] 0.31 0.52
Current BMI 1.47 [1.05-2.07] 0.02 0.99 [0.88-1.12] 0.91 0.14
BMI gain, age 20-40 1.05 [0.60-1.85] 0.85 0.85 [0.70-1.03] 0.09 0.46
BMI gain, age 40-50 2.06 [1.09-3.88] 0.02 1.29 [1.00-1.65] 0.05 0.40
BMI gain, age 50 to current age 1.62 [0.96-2.74] 0.06 0.94 [0.76-1.15] 0.53 0.28
  Age < 65 y Age ≥ 65 y p interaction
  (469 cases / 500 controls) (270 cases / 315 controls)
  ORa 95 % CI p trendb ORa 95 % CI p trendb
BMI at age 20 1.04 [0.82-1.33] 0.74 1.07 [0.77-1.47] 0.69 0.76
BMI at age 50 1.03 [0.88-1.21] 0.68 1.27 [0.98-1.63] 0.06 0.07
Current BMI 0.97 [0.84-1.11] 0.66 1.18 [0.98-1.42] 0.08 0.08
BMI gain, age 20-40 0.83 [0.67-1.04] 0.10 1.06 [0.74-1.50] 0.75 0.20
BMI gain, age 40-50 1.24 [0.95-1.61] 0.11 1.88 [1.14-3.07] 0.01 0.08
BMI gain, age 50 to current age 0.97 [0.74-1.27] 0.82 1.04 [0.80-1.36] 0.76 0.87
  Current MHT users Non MHT users p interaction
  (150 cases / 125 controls) (589 cases / 690 controls)
  ORa 95 % CI p trend b ORa 95 % CI p trendb
BMI at age 20 0.97 [0.54-1.74] 0.91 1.03 [0.84-1.26] 0.81 0.81
BMI at age 50 1.05 [0.69-1.60] 0.81 1.07 [0.93-1.24] 0.31 0.75
Current BMI 1.08 [0.77-1.50] 0.65 1.03 [0.92-1.16] 0.63 0.90
BMI gain, age 20-40 1.27 [0.72-2.24] 0.40 0.86 [0.70-1.04] 0.13 0.73
BMI gain, age 40-50 1.02 [0.47-2.20] 0.97 1.37 [1.08-1.74] 0.01 0.34
BMI gain, age 50 to current age 1.06 [0.59-1.88] 0.85 1.00 [0.82-1.22] 0.99 0.69
  1. aORs adjusted for study area, age, age at menarche, parity, age at first full-term pregnancy, breastfeeding, family history of breast cancer, OC use, current use of MHT (where appropriate), alcohol consumption, tobacco smoking, and physical activity
  2. bp for trend calculated from the model using BMI or BMI change as continuous variables